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1V209

Name: 1V209
Brand: TargetMol
SKU: T8316
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8316Cas No. 1062444-54-5

Alias TLR7 agonist T7

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist known for its anti-tumor properties.

1V209

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Purity: 99.61%

Catalog No. T8316Alias TLR7 agonist T7Cas No. 1062444-54-5

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist known for its anti-tumor properties.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$77	In Stock
25 mg	$172	In Stock
50 mg	$250	In Stock
100 mg	$353	In Stock
200 mg	$503	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock

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Batch Information

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Purity:99.61%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist known for its anti-tumor properties.
In vitro	The small molecule synthetic TLR7 ligand, 2-methoxyethoxy-8-oxo-9-(4-carboxy benzyl)adenine (1V209), and α-mannose were coimmobilized via linker molecules consisting of thioctic acid on the GNP surface (1V209-αMan-GNPs).?The in vitro cytokine production activity of 1V209-αMan-GNPs was higher than that of the unconjugated 1V209 derivative in mouse bone marrow-derived dendritic cells and in human peripheral blood mononuclear cells[1].
In vivo	In the in vivo immunization study, 1V209-αMan-GNPs induced significantly higher titers of IgG2c antibody specific to ovalbumin as an antigen than did unconjugated 1V209, and splenomegaly and weight loss were not observed[1].
Synonyms	TLR7 agonist T7

Chemical Properties

Molecular Weight	359.34
Formula	C₁₆H₁₇N₅O₅
Cas No.	1062444-54-5
Smiles	COCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(cc3)C(O)=O)c2n1
Relative Density.	1.466 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (231.90 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7829 mL	13.9144 mL	27.8288 mL	139.1440 mL
5 mM	0.5566 mL	2.7829 mL	5.5658 mL	27.8288 mL
10 mM	0.2783 mL	1.3914 mL	2.7829 mL	13.9144 mL
20 mM	0.1391 mL	0.6957 mL	1.3914 mL	6.9572 mL
50 mM	0.0557 mL	0.2783 mL	0.5566 mL	2.7829 mL
100 mM	0.0278 mL	0.1391 mL	0.2783 mL	1.3914 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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