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Dehydroabiethylamine

Name: Dehydroabiethylamine
Brand: TargetMol
SKU: T19783
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19783Cas No. 1446-61-3

Alias NSC-2955, NSC2955, NSC 2955, Leelamine free base, Leelamine, Dehydroabietylamine

Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity.

Dehydroabiethylamine

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Purity: 98.79%

Catalog No. T19783Alias NSC-2955, NSC2955, NSC 2955, Leelamine free base, Leelamine, DehydroabietylamineCas No. 1446-61-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$33	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.79%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Dehydroabiethylamine AI Summary

Dehydroabiethylamine exhibits a broad spectrum of biological activities and cytotoxic effects. It shows in vitro inhibitory activity against pyruvate dehydrogenase kinase with an IC50 of 9500.0 nM. The compound demonstrates improvements in efficacy ranging from -4.0% to 90.0% in diabetic mice. It also inhibits Nrf2, the mitochondrial permeability transition pore, hepatitis C virus (HCV), and human tyrosyl-DNA phosphodiesterase 1 (TDP1), and induces DNA re-replication and synthetic lethality in certain tumor cells with potencies ranging from 4466.8 nM to 100000.0 nM. In human EJ cells, Dehydroabiethylamine induces apoptosis, with significant early apoptotic activity (87.9%) and minor necrotic effects (0.13%). Additionally, it exhibits hemolytic activity (17.88%) in mouse red blood cells. Its cytotoxicity across various human cell lines shows IC50 values between 4820.0 nM and 8700.0 nM after 72 hours. Dehydroabiethylamine shows significant antiparasitic activities, including antileishmanial effects against Leishmania donovani with 68.7% growth inhibition at 50 uM, and antitrypanosomal efficacy against Trypanosoma cruzi with an IC50 of 7400.0 nM. It also exhibits cytotoxicity towards rat L6 cells with an IC50 of 6500.0 nM, yielding a selectivity index of 1.0. Moreover, the compound has antiproliferative and cytotoxic effects on various human cell lines, including HUVEC cells (IC50 of 1270.0 nM) and multiple cancer cell lines such as A549, MCF7, HepG2, and HeLa with varying IC50 values. It induces apoptosis in HepG2 cells in a dose-dependent fashion. The compound also shows selective cytotoxicity towards human over mouse cell lines and demonstrates partial inhibition of human HDAC6 activity depending on the peptide substrate used..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity.
Synonyms	NSC-2955, NSC2955, NSC 2955, Leelamine free base, Leelamine, Dehydroabietylamine

Chemical Properties

Molecular Weight	285.47
Formula	C₂₀H₃₁N
Cas No.	1446-61-3
Smiles	[H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(C)CN)C(C)C
Relative Density.	0.963 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (87.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5030 mL	17.5150 mL	35.0300 mL	175.1498 mL
5 mM	0.7006 mL	3.5030 mL	7.0060 mL	35.0300 mL
10 mM	0.3503 mL	1.7515 mL	3.5030 mL	17.5150 mL
20 mM	0.1751 mL	0.8757 mL	1.7515 mL	8.7575 mL
50 mM	0.0701 mL	0.3503 mL	0.7006 mL	3.5030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc