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Dehydroabiethylamine

Name: Dehydroabiethylamine
Brand: TargetMol
SKU: T19783
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T19783Cas No. 1446-61-3

Alias NSC-2955, NSC2955, NSC 2955, Leelamine free base, Leelamine, Dehydroabietylamine

Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity.

Dehydroabiethylamine

🥰Excellent

Purity: 98.79%

Catalog No. T19783Alias NSC-2955, NSC2955, NSC 2955, Leelamine free base, Leelamine, DehydroabietylamineCas No. 1446-61-3

Pack Size	Price	Availability	Quantity
1 g	$33	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:98.79%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity.
Synonyms	NSC-2955, NSC2955, NSC 2955, Leelamine free base, Leelamine, Dehydroabietylamine

Chemical Properties

Molecular Weight	285.47
Formula	C₂₀H₃₁N
Cas No.	1446-61-3
Smiles	[H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(C)CN)C(C)C
Relative Density.	0.963 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (87.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5030 mL	17.5150 mL	35.0300 mL	175.1498 mL
5 mM	0.7006 mL	3.5030 mL	7.0060 mL	35.0300 mL
10 mM	0.3503 mL	1.7515 mL	3.5030 mL	17.5150 mL
20 mM	0.1751 mL	0.8757 mL	1.7515 mL	8.7575 mL
50 mM	0.0701 mL	0.3503 mL	0.7006 mL	3.5030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc