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Ibrexafungerp citrate

Name: Ibrexafungerp citrate
Brand: TargetMol
SKU: T70029
Rating: 4.5 (1 reviews)

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Catalog No. T70029Cas No. 1965291-08-0

Alias SCY-078 citrate, SCY078 citrate, MK3118 citrate, MK 3118 citrate

Ibrexafungerp citrate is a triterpenoid antifungal agent that inhibits the synthesis of 1,3-β-D-glucan in fungal cell walls, and although its functional outcome is similar to echinocandins, it binds to a distinct site on the glucan synthase enzyme, resulting in limited cross-resistance. Ibrexafungerp citrate exhibit concentration-dependent fungicidal activity against Candida species and retaining strong in vitro efficacy against the majority of fluconazole-resistant strains, supporting its use in antifungal resistance and drug development research.

Ibrexafungerp citrate

😃Good

Catalog No. T70029Alias SCY-078 citrate, SCY078 citrate, MK3118 citrate, MK 3118 citrateCas No. 1965291-08-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry
100 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Ibrexafungerp citrate is a triterpenoid antifungal agent that inhibits the synthesis of 1,3-β-D-glucan in fungal cell walls, and although its functional outcome is similar to echinocandins, it binds to a distinct site on the glucan synthase enzyme, resulting in limited cross-resistance. Ibrexafungerp citrate exhibit concentration-dependent fungicidal activity against Candida species and retaining strong in vitro efficacy against the majority of fluconazole-resistant strains, supporting its use in antifungal resistance and drug development research.
In vitro	In fungal susceptibility assays, Ibrexafungerp citrate acted as a β-1,3-glucan synthase inhibitor, disrupting cell wall integrity. It exhibited a minimum inhibitory concentration (MIC50) of 0.5 μg/mL against various Candida species, including multidrug-resistant Candida auris, resulting in broad-spectrum fungicidal activity [1].
Synonyms	SCY-078 citrate, SCY078 citrate, MK3118 citrate, MK 3118 citrate

Chemical Properties

Molecular Weight	922.16
Formula	C₅₀H₇₅N₅O₁₁
Cas No.	1965291-08-0
Smiles	C(CC(O)=O)(CC(O)=O)(C(O)=O)O.C[C@@]12[C@]3([C@@](C=4[C@@]([C@]5(C)[C@@](C)(CC4)[C@H](C(O)=O)[C@]([C@@H](C(C)C)C)(C)CC5)(CC3)[H])(C[C@H]([C@@H]1OC[C@](C(C)(C)C)(C)N)N6C(=NC=N6)C=7C=CN=CC7)COC2)[H]

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (86.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0844 mL	5.4221 mL	10.8441 mL	54.2205 mL
5 mM	0.2169 mL	1.0844 mL	2.1688 mL	10.8441 mL
10 mM	0.1084 mL	0.5422 mL	1.0844 mL	5.4221 mL
20 mM	0.0542 mL	0.2711 mL	0.5422 mL	2.7110 mL
50 mM	0.0217 mL	0.1084 mL	0.2169 mL	1.0844 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc