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Ibrexafungerp citrate

Name: Ibrexafungerp citrate
Brand: TargetMol
SKU: T70029
Rating: 4.5 (1 reviews)

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Catalog No. T70029Cas No. 1965291-08-0

Alias SCY-078 citrate, SCY078 citrate, MK3118 citrate, MK 3118 citrate

Ibrexafungerp citrate is a triterpenoid antifungal agent that inhibits the synthesis of 1,3-β-D-glucan in fungal cell walls, and although its functional outcome is similar to echinocandins, it binds to a distinct site on the glucan synthase enzyme, resulting in limited cross-resistance. Ibrexafungerp citrate exhibit concentration-dependent fungicidal activity against Candida species and retaining strong in vitro efficacy against the majority of fluconazole-resistant strains, supporting its use in antifungal resistance and drug development research.

Ibrexafungerp citrate

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Catalog No. T70029Alias SCY-078 citrate, SCY078 citrate, MK3118 citrate, MK 3118 citrateCas No. 1965291-08-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry
100 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Ibrexafungerp citrate is a triterpenoid antifungal agent that inhibits the synthesis of 1,3-β-D-glucan in fungal cell walls, and although its functional outcome is similar to echinocandins, it binds to a distinct site on the glucan synthase enzyme, resulting in limited cross-resistance. Ibrexafungerp citrate exhibit concentration-dependent fungicidal activity against Candida species and retaining strong in vitro efficacy against the majority of fluconazole-resistant strains, supporting its use in antifungal resistance and drug development research.
In vitro	In fungal susceptibility assays, Ibrexafungerp citrate acted as a β-1,3-glucan synthase inhibitor, disrupting cell wall integrity. It exhibited a minimum inhibitory concentration (MIC50) of 0.5 μg/mL against various Candida species, including multidrug-resistant Candida auris, resulting in broad-spectrum fungicidal activity [1].
Synonyms	SCY-078 citrate, SCY078 citrate, MK3118 citrate, MK 3118 citrate

Chemical Properties

Molecular Weight	922.16
Formula	C₅₀H₇₅N₅O₁₁
Cas No.	1965291-08-0
Smiles	C(CC(O)=O)(CC(O)=O)(C(O)=O)O.C[C@@]12[C@]3([C@@](C=4[C@@]([C@]5(C)[C@@](C)(CC4)[C@H](C(O)=O)[C@]([C@@H](C(C)C)C)(C)CC5)(CC3)[H])(C[C@H]([C@@H]1OC[C@](C(C)(C)C)(C)N)N6C(=NC=N6)C=7C=CN=CC7)COC2)[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (86.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0844 mL	5.4221 mL	10.8441 mL	54.2205 mL
5 mM	0.2169 mL	1.0844 mL	2.1688 mL	10.8441 mL
10 mM	0.1084 mL	0.5422 mL	1.0844 mL	5.4221 mL
20 mM	0.0542 mL	0.2711 mL	0.5422 mL	2.7110 mL
50 mM	0.0217 mL	0.1084 mL	0.2169 mL	1.0844 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc