Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS9449 is a potent PROTAC EGFR degrader, exhibiting dissociation constants (Kd) of 17 nM for EGFR WT and 10 nM for EGFR L858R. It effectively mediates the degradation of mutant EGFRs via both ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways, and robustly suppresses the proliferation of NSCLC cells, indicating its potential utility in anticancer research [1].
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50 mg | Inquiry | Inquiry |
Description | MS9449 is a potent PROTAC EGFR degrader, exhibiting dissociation constants (Kd) of 17 nM for EGFR WT and 10 nM for EGFR L858R. It effectively mediates the degradation of mutant EGFRs via both ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways, and robustly suppresses the proliferation of NSCLC cells, indicating its potential utility in anticancer research [1]. |
Targets&IC50 | EGFR (WT):17 nM (Kd), EGFR L858R:10 nM (Kd) |
Molecular Weight | 1151.82 |
Formula | C60H76ClFN10O8S |
CAS No. | 2772612-96-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MS9449 2772612-96-9 PROTAC PROTACs inhibitor inhibit