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Alkynyl Palmitic Acid

Name: Alkynyl Palmitic Acid
Brand: TargetMol
SKU: T14185
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14185Cas No. 99208-90-9

Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis.

Alkynyl Palmitic Acid

🥰Excellent

Purity: 98.1%

Catalog No. T14185Cas No. 99208-90-9

Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis.

Pack Size	Price	Availability
1 mg	$59	In Stock
5 mg	$118	In Stock
10 mg	$197	In Stock
25 mg	$239	In Stock
50 mg	$383	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock

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Batch Information

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Purity:98.1%

Resource Download

COA GC HNMR

Product Introduction

Bioactivity

Description

Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis.

In vitro

PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation.

Chemical Properties

Molecular Weight	252.39
Formula	C₁₆H₂₈O₂
Cas No.	99208-90-9
Smiles	C(CCCCCCCCC#C)CCCCC(O)=O
Relative Density.	0.9310 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (396.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9621 mL	19.8106 mL	39.6212 mL	198.1061 mL
5 mM	0.7924 mL	3.9621 mL	7.9242 mL	39.6212 mL
10 mM	0.3962 mL	1.9811 mL	3.9621 mL	19.8106 mL
20 mM	0.1981 mL	0.9905 mL	1.9811 mL	9.9053 mL
50 mM	0.0792 mL	0.3962 mL	0.7924 mL	3.9621 mL
100 mM	0.0396 mL	0.1981 mL	0.3962 mL	1.9811 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc