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IMS2186
🥰Excellent
Catalog No. T67746Cas No. 1031206-36-6
IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the amount of eye leakage and diseased cells with no intraocular toxicity.
IMS2186
🥰Excellent
Purity: 99.96%
Catalog No. T67746Cas No. 1031206-36-6
IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the amount of eye leakage and diseased cells with no intraocular toxicity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $41 | In Stock | |
| 25 mg | $95 | In Stock | |
| 50 mg | $141 | In Stock | |
| 100 mg | $207 | In Stock | |
| 200 mg | $296 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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Purity:99.96%
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Product Introduction
Bioactivity
Chemical Properties
| Description | IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the amount of eye leakage and diseased cells with no intraocular toxicity. |
| In vitro | IMS2186 (0.3-10 μM; 22 h) inhibits the proliferation of human fibroblasts and human cancer cells with IC50 values of 1.0-3.0 μM and 0.3-3.0 μM, respectively. IMS2186 (0-10 μM; 22 h) also inhibits endothelium formation with an IC50 of 0.1-0.3 μM under 10 ng/mL VEGF stimulation. Additionally, IMS2186 (0.1-10 μM; 24 h) inhibits the production of pro-inflammatory cytokines PGE2/TNF-a in macrophages with an IC50 of 0.3-1 μM, and it inhibits macrophage migration with an IC50 of 1 μM within 1.5 hours[1]. |
| In vivo | IMS2186 (2.5 mg in 0.5 mL; vitreous injection; single dose) was administered to rabbit eyes with no ocular toxicity, and IMS2186 (100 μg/eye, i.e. 50 μg/μL solution dosage 2.0 μL; single dose) exhibited an anti-proliferative effect on the rat model of laser-induced choroidal neovascularization (CNV) [1]. |
| Molecular Weight | 296.32 |
| Formula | C18H16O4 |
| Cas No. | 1031206-36-6 |
| Smiles | COc1ccc(\C=C2/COc3ccc(C)cc3C2=O)cc1O |
| Relative Density. | 1.286 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (202.48 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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