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AMG-009

Name: AMG-009
Brand: TargetMol
SKU: T14211
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14211Cas No. 1027847-67-1

AMG-009 is a selective and potent dual antagonist of CRTH2 and DP, with an IC50 value of 3 nM for CRTH2 and 12 nM for DP receptors.

AMG-009

🥰Excellent

Purity: 97.88%

Catalog No. T14211Cas No. 1027847-67-1

AMG-009 is a selective and potent dual antagonist of CRTH2 and DP, with an IC50 value of 3 nM for CRTH2 and 12 nM for DP receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$92	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$223	In Stock	In Stock
50 mg	$392	In Stock	In Stock
100 mg	$668	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.88%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	AMG-009 is a selective and potent dual antagonist of CRTH2 and DP, with an IC50 value of 3 nM for CRTH2 and 12 nM for DP receptors.
Targets&IC50	CRTH2/DP2 Receptor:3 nM
In vitro	AMG-009 inhibits PGD2-induced down-modulation of CRTH2 on CD16 negative eosinophils in human whole blood with a Ki of 1 nM[1].
In vivo	AMG 009 (3, 10, or 30 mg/kg, s.c.) dose-dependently decreases PGD2 aerosol-induced airway resistance and significantly enhances DP potency (Kb of 82 nM) in an acute guinea pig model[1][2].

Chemical Properties

Molecular Weight	581.47
Formula	C₂₆H₂₆Cl₂N₂O₇S
Cas No.	1027847-67-1
Smiles	O=C(O)CC1=CC=C(OC2=CC=C(C=C2NS(=O)(=O)C3=CC=C(Cl)C=C3Cl)C(=O)NCCCC)C(OC)=C1
Relative Density.	1.403 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (171.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7198 mL	8.5989 mL	17.1978 mL	85.9890 mL
5 mM	0.3440 mL	1.7198 mL	3.4396 mL	17.1978 mL
10 mM	0.1720 mL	0.8599 mL	1.7198 mL	8.5989 mL
20 mM	0.0860 mL	0.4299 mL	0.8599 mL	4.2994 mL
50 mM	0.0344 mL	0.1720 mL	0.3440 mL	1.7198 mL
100 mM	0.0172 mL	0.0860 mL	0.1720 mL	0.8599 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc