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4-Methylumbelliferone

Name: 4-Methylumbelliferone
Brand: TargetMol
SKU: T1391
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1391Cas No. 90-33-5

Alias Hymecromone, 4-MU

4-Methylumbelliferone (Hymecromone) is a coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.

4-Methylumbelliferone

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Purity: 97.70%

Catalog No. T1391Alias Hymecromone, 4-MUCas No. 90-33-5

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$38	In Stock	In Stock
100 mg	$54	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.70%

Appearance:Solid

Color:White

Resource Download

COA HPLC LCMS HNMR

Product Introduction

4-Methylumbelliferone AI Summary

4-Methylumbelliferone exhibits a diverse range of bioactivities across various assays and targets. It has a pKa value of 7.8, indicating its acidity or basicity at specific pH levels. The compound shows photostability and bioactivity, including noncompetitive inhibition of rat lens aldose reductase with an IC50 of 62,000.0 nM and induction of apoptosis in human U937 cells at 250 µM concentration. It also demonstrates cytotoxicity, growth inhibition, and apoptotic activity against human U937 cells, with varying IC50 and CC50 values. In enzymatic assays, 4-Methylumbelliferone inhibits human 17beta-HSD3 with an IC50 of 1000.0 nM, alpha-glucosidase with an IC50 of 56200.0 nM, and human recombinant CA9 and CA12 with Ki values of 560.0 nM and 8100.0 nM, respectively. It also inhibits electric eel acetylcholinesterase and human recombinant MAOB with potencies at high nanomolar concentrations. The compound exhibits moderate to low bioactivity in antiviral assays, specifically against SARS-CoV-2, with varying degrees of cytotoxicity inhibition. It also demonstrates modest antibacterial and antifungal activities against various strains, including Helicobacter pylori, and shows anti-inflammatory properties by inhibiting LPS-stimulated inflammatory markers in mouse cells. Additionally, 4-Methylumbelliferone shows activity in the formation of glucosides by interacting with Streptomyces antibioticus OleD, and its antioxidant activity is apparent in DPPH and ABTS radical scavenging assays. It also demonstrates inhibition of HDAC6 and has been evaluated for metabolic stability, displaying differential stability in mouse and human liver microsomes. Overall, 4-Methylumbelliferone is a multifaceted compound with potential applications in combating microbial infections, anti-inflammatory treatments, enzyme inhibition, and possibly antiviral therapy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4-Methylumbelliferone (Hymecromone) is a coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.
Synonyms	Hymecromone, 4-MU

Chemical Properties

Molecular Weight	176.17
Formula	C₁₀H₈O₃
Cas No.	90-33-5
Smiles	CC1=CC(=O)OC2=C1C=CC(O)=C2
Relative Density.	1.319 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 33 mg/mL (187.32 mM), Sonication is recommended.

DMSO: 250 mg/mL (1419.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (22.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6763 mL	28.3817 mL	56.7634 mL	283.8168 mL
5 mM	1.1353 mL	5.6763 mL	11.3527 mL	56.7634 mL
10 mM	0.5676 mL	2.8382 mL	5.6763 mL	28.3817 mL
20 mM	0.2838 mL	1.4191 mL	2.8382 mL	14.1908 mL
50 mM	0.1135 mL	0.5676 mL	1.1353 mL	5.6763 mL
100 mM	0.0568 mL	0.2838 mL	0.5676 mL	2.8382 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc