Thalidomide-O-amido-C8-NH2

Name: Thalidomide-O-amido-C8-NH2
Brand: TargetMol
SKU: T17819
Rating: 4.5 (1 reviews)

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Catalog No. T17819Cas No. 1950635-15-0

Alias E3 Ligase Ligand-Linker Conjugates 20, Cereblon Ligand-Linker Conjugates 2

Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker, useful in the synthesis of PROTACs, as per reference [1].

Thalidomide-O-amido-C8-NH2

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Catalog No. T17819Alias E3 Ligase Ligand-Linker Conjugates 20, Cereblon Ligand-Linker Conjugates 2Cas No. 1950635-15-0

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Product Introduction

Bioactivity

Description	Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker, useful in the synthesis of PROTACs, as per reference [1].
In vitro	Thalidomide-O-amido-C8-NH2, referred to as Compound DL7-TL, serves as a degron-linker within the PROTAC framework, covalently connecting to both a degron and a targeting ligand. This configuration enables the degron, a molecule that binds to ubiquitin ligases (e.g., cereblon), to guide the targeting ligand toward specific proteins[1], facilitating their ubiquitination and subsequent degradation.
Synonyms	E3 Ligase Ligand-Linker Conjugates 20, Cereblon Ligand-Linker Conjugates 2

Chemical Properties

Molecular Weight	458.51
Formula	C₂₃H₃₀N₄O₆
Cas No.	1950635-15-0
Smiles	O=C(NCCCCCCCCN)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Relative Density.	1.295 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc