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Macimorelin acetate (Synonyms: EP-1572 acetate, AEZS-130 acetate)

Name: Macimorelin acetate
Brand: TargetMol
SKU: T68276
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T68276 Copy Product Info

Purity: 99.98%

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Macimorelin acetate is an orally active agonist of the GHSR (Growth Hormone Secretagogue Receptor) and functions as a growth hormone (GH) secretagogue. As a ghrelin mimetic, it potently stimulates the release of endogenous growth hormone by binding to GHSR. Macimorelin acetate is clinically utilized as a diagnostic tool for Adult Growth Hormone Deficiency (AGHD) and is being investigated for the treatment of Cancer Anorexia-Cachexia Syndrome (CACS). Additionally, it has shown potential in neurological research for suppressing seizure activity.

Macimorelin acetate

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Catalog No. T68276

Synonyms EP-1572 acetate, AEZS-130 acetate

Cas No. 945212-59-9

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Pack Size	Price	USA Stock	Global Stock
1 mg	$63	-	In Stock
5 mg	$148	-	In Stock
10 mg	$242	-	In Stock
25 mg	$469	-	In Stock
50 mg	$673	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Macimorelin acetate is an orally active agonist of the GHSR (Growth Hormone Secretagogue Receptor) and functions as a growth hormone (GH) secretagogue. As a ghrelin mimetic, it potently stimulates the release of endogenous growth hormone by binding to GHSR. Macimorelin acetate is clinically utilized as a diagnostic tool for Adult Growth Hormone Deficiency (AGHD) and is being investigated for the treatment of Cancer Anorexia-Cachexia Syndrome (CACS). Additionally, it has shown potential in neurological research for suppressing seizure activity.
In vitro	NFATc1-IN-1 (0、0.5、1.0、1.5、2.0、2.5 μM, 4 days) exhibits potent inhibitory activities on osteoclast formation and function, which eventually translates into decreased bone resorption while showing no cytotoxic effects towards osteoclast precursor cells at concentrations of as high as 2.5 μM.[1] NFATc1-IN-1 (1.5-2.5 μM, 24 h) blocks NFATc1 nuclear translocation and decreases the level of NFATc1.[1]
In vivo	Macimorelin acetate suppresses acute seizures in epileptic mice (5 mg/kg, i.p.) but lacks long-term antiepileptic effects [2]. Orally, it rapidly and dose-dependently increases GH levels, serving as an effective diagnostic for AGHD [1].
Synonyms	EP-1572 acetate, AEZS-130 acetate

Chemical Properties

Molecular Weight	534.61
Formula	C₂₈H₃₄N₆O₅
Cas No.	945212-59-9
Smiles	C(C)(O)=O.C([C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)NC=O)=O)NC(C(C)(C)N)=O)C=3C=4C(NC3)=CC=CC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (149.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8705 mL	9.3526 mL	18.7052 mL	93.5261 mL
5 mM	0.3741 mL	1.8705 mL	3.7410 mL	18.7052 mL
10 mM	0.1871 mL	0.9353 mL	1.8705 mL	9.3526 mL
20 mM	0.0935 mL	0.4676 mL	0.9353 mL	4.6763 mL
50 mM	0.0374 mL	0.1871 mL	0.3741 mL	1.8705 mL
100 mM	0.0187 mL	0.0935 mL	0.1871 mL	0.9353 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc