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Anti-Phospho-MLKL (Ser358) Antibody (8V821)
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Catalog No. TMAH-00928
Alias p-MLKL (Ser358), p-MLKL (S358), Phospho-MLKL (S358), MLKL (p-Ser358), MLKL (p-S358)
Anti-Phospho-MLKL (Ser358) Antibody (8V821) is an antibody targeting Phospho-MLKL (Ser358). Anti-Phospho-MLKL (Ser358) Antibody (8V821) can be used in ELISA, IHC.
Anti-Phospho-MLKL (Ser358) Antibody (8V821)
Anti-Phospho-MLKL (Ser358) Antibody (8V821)
😃Good
Catalog No. TMAH-00928Alias p-MLKL (Ser358), p-MLKL (S358), Phospho-MLKL (S358), MLKL (p-Ser358), MLKL (p-S358)
Anti-Phospho-MLKL (Ser358) Antibody (8V821) is an antibody targeting Phospho-MLKL (Ser358). Anti-Phospho-MLKL (Ser358) Antibody (8V821) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, IHC Reactivity: Human |
| Alias | p-MLKL (Ser358), p-MLKL (S358), Phospho-MLKL (S358), MLKL (p-Ser358), MLKL (p-S358) |
| Ig Type | Rabbit IgG |
| Clone | 8V821 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00928 diluted at 1:100 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Cell membrane. Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-MLKL (S358) |
| Antigen Species | Human |
| Gene ID | 197259 |
| Uniprot ID | |
| Biology Area | Signal Transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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