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GNE-9822

Name: GNE-9822
Brand: TargetMol
SKU: T31982
Price: 178 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31982Cas No. 1557232-32-2

Alias GNE9822, GNE 9822

GNE-9822 is a potent, orally active, and selective interleukin-2–inducible T-cell kinase (ITK) inhibitor with a Ki value of 0.7 nM and an EC50 value of 354.5 nM, exhibiting favorable ADME properties, GNE-9822 is extensively used in asthma and immunology research to explore T-cell signaling modulation and targeted anti-inflammatory therapeutic strategies.

GNE-9822

😃Good

Purity: 99.90%

Catalog No. T31982Alias GNE9822, GNE 9822Cas No. 1557232-32-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$178	-	In Stock
5 mg	$446	-	In Stock
10 mg	$728	-	In Stock
25 mg	$1,080	-	In Stock
50 mg	$1,480	-	In Stock
100 mg	$1,960	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.90%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	GNE-9822 is a potent, orally active, and selective interleukin-2–inducible T-cell kinase (ITK) inhibitor with a Ki value of 0.7 nM and an EC50 value of 354.5 nM, exhibiting favorable ADME properties, GNE-9822 is extensively used in asthma and immunology research to explore T-cell signaling modulation and targeted anti-inflammatory therapeutic strategies.
Targets&IC50	ITK:354.5 nM (EC50)
In vitro	In cellular assays, GNE-9822 functioned as an inhibitor of Interleukin-2 Inducible T-Cell Kinase (ITK), inhibiting the phosphorylation of the downstream substrate Phospholipase C γ (PLCγ) with an IC50 of 55 nM. It was also referenced in degradation studies with an EC50 of 354.5 nM against ITK [1].
Synonyms	GNE9822, GNE 9822

Chemical Properties

Molecular Weight	420.55
Formula	C₂₄H₃₂N₆O
Cas No.	1557232-32-2
Smiles	C(NC1=CN([C@@H](CCN(C)C)C2=CC=CC=C2)N=C1)(=O)C=3C4=C(NN3)CC(C)(C)CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (118.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3778 mL	11.8892 mL	23.7784 mL	118.8919 mL
5 mM	0.4756 mL	2.3778 mL	4.7557 mL	23.7784 mL
10 mM	0.2378 mL	1.1889 mL	2.3778 mL	11.8892 mL
20 mM	0.1189 mL	0.5945 mL	1.1889 mL	5.9446 mL
50 mM	0.0476 mL	0.2378 mL	0.4756 mL	2.3778 mL
100 mM	0.0238 mL	0.1189 mL	0.2378 mL	1.1889 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc