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UCM 608

Name: UCM 608
Brand: TargetMol
SKU: T22499
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22499Cas No. 151889-03-1

Alias UCM608, 2-Phenylmelatonin

UCM 608 (2-Phenylmelatonin) is an antagonist of melatonin-induced contractile responses at low concentrations and induces an increase in GDP-GTP exchange.

UCM 608

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Purity: 98.88%

Catalog No. T22499Alias UCM608, 2-PhenylmelatoninCas No. 151889-03-1

UCM 608 (2-Phenylmelatonin) is an antagonist of melatonin-induced contractile responses at low concentrations and induces an increase in GDP-GTP exchange.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$46	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$168	In Stock	In Stock
50 mg	$247	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.88%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	UCM 608 (2-Phenylmelatonin) is an antagonist of melatonin-induced contractile responses at low concentrations and induces an increase in GDP-GTP exchange.
Targets&IC50	MT1 receptor:10.7 (pKi), MT2 receptor:10.4 (pKi)
In vitro	UCM 608 is an agonist with high affinity for melatonin membrane receptors. Its pKi values for MT1 and MT2 receptors are 10.7 and 10.4, respectively. [1]
Synonyms	UCM608, 2-Phenylmelatonin

Chemical Properties

Molecular Weight	308.37
Formula	C₁₉H₂₀N₂O₂
Cas No.	151889-03-1
Smiles	O=C(NCCC=1C=2C=C(OC)C=CC2NC1C=3C=CC=CC3)C
Relative Density.	1.172g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (64.86 mM), Sonication is recommended.

Ethanol: 20 mg/mL (64.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.24 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.2429 mL	16.2143 mL	32.4286 mL	162.1429 mL
5 mM	0.6486 mL	3.2429 mL	6.4857 mL	32.4286 mL
10 mM	0.3243 mL	1.6214 mL	3.2429 mL	16.2143 mL
20 mM	0.1621 mL	0.8107 mL	1.6214 mL	8.1071 mL
50 mM	0.0649 mL	0.3243 mL	0.6486 mL	3.2429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc