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SGD-1882

Name: SGD-1882
Brand: TargetMol
SKU: T19560
Rating: 4.5 (1 reviews)

(Synonyms: SGD1882, PBD dimer) Copy Product Info

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Synonyms: SGD1882, PBD dimer

Catalog No. T19560 Copy Product Info

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SGD-1882 (PBD dimer) is a potent DNA alkylating/crosslinking agent serving as a cytotoxic PBD-class antibody-drug conjugate (ADC) payload molecule. SGD-1882 exhibits targeting properties toward mouse and human hematopoietic stem cells (HSCs) and acute myeloid leukemia cells.SGD-1882 can be used in ADC drug development.

Cas No. 1222490-34-7

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$1,264	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	SGD-1882 (PBD dimer) is a potent DNA alkylating/crosslinking agent serving as a cytotoxic PBD-class antibody-drug conjugate (ADC) payload molecule. SGD-1882 exhibits targeting properties toward mouse and human hematopoietic stem cells (HSCs) and acute myeloid leukemia cells.SGD-1882 can be used in ADC drug development.
Targets & IC50	AML cells 3:0.25 pM, AML cells 2:0.22 pM, SHI cells:0.28 pM, A704 cells:9.85 pM, HL-60 cells:1.58 pM, AML cells 5:0.14 pM, HepG2 cells:121 pM
In vitro	Methods: Primary AML1 mouse leukemia cells were treated with a concentration gradient of CD45.2-PBD and CD45.2-PNU (0.0003–20 μg/mL) for 72 hours, followed by cell viability assessment using the CellTiter-Glo assay. Results: Both CD45.2-PBD and CD45.2-PNU exhibited potent cytotoxicity against AML1 cells. [1] Methods: WSU-DLCL2 lymphoma cells were treated with SGD-1882-CD19B (0.1, 1, 10 ng/mL) or free SGD-1882 (0.001, 0.01, 0.1 nM) for 48 hours. γ-H2AX (a DNA damage marker) was detected by Western Blot. Results: Both SGD-1882-CD19B and free SGD-1882 induced dose-dependent increases in γ-H2AX levels, indicating DNA damage. [2]
In vivo	Methods: C57BL/6 mice received a single intravenous injection of different CD45.2-ADC (60 μg). Bone marrow, spleen, and peripheral blood were analyzed 7 days later. Results: CD45.2-PBD and CD45.2-PNU significantly depleted phenotypic HSCs and progenitor cells in bone marrow and reduced colony-forming capacity. [1] Methods: CB-17 SCID mice subcutaneously implanted with WSU-DLCL2 (human DLBCL, double-hit lymphoma) cells received a single intravenous dose of SGD-1882-CD19B (100 or 300 μg/kg) when tumor volume reached approximately 100 mm³, with a control group receiving ADC (300 μg/kg). Animals were observed for approximately 60 days. Results: In the 300 μg/kg SGD-1882-CD19B group, 100% of mice achieved complete tumor regression that persisted until the end of the experiment. The 100 μg/kg group demonstrated significant tumor growth delay. [2]
Synonyms	SGD1882, PBD dimer

Chemical Properties

Molecular Weight	725.79
Formula	C₄₂H₃₉N₅O₇
Cas No.	1222490-34-7
Smiles	O=C1N2[C@@](CC(=C2)C3=CC=C(OC)C=C3)(C=NC=4C1=CC(OC)=C(OCCCOC5=C(OC)C=C6C(=C5)N=C[C@]7(N(C6=O)C=C(C7)C8=CC=C(N)C=C8)[H])C4)[H]
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (110.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3778 mL	6.8890 mL	13.7781 mL	68.8905 mL
5 mM	0.2756 mL	1.3778 mL	2.7556 mL	13.7781 mL
10 mM	0.1378 mL	0.6889 mL	1.3778 mL	6.8890 mL
20 mM	0.0689 mL	0.3445 mL	0.6889 mL	3.4445 mL
50 mM	0.0276 mL	0.1378 mL	0.2756 mL	1.3778 mL
100 mM	0.0138 mL	0.0689 mL	0.1378 mL	0.6889 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.