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SGD-1882

Name: SGD-1882
Brand: TargetMol
SKU: T19560
Rating: 4.5 (1 reviews)

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Catalog No. T19560Cas No. 1222490-34-7

Alias SGD1882, PBD dimer

SGD-1882 (PBD dimer) is a cytotoxic conjugate that is a target for mouse and human hematopoietic stem cells (HSC) and acute myeloid leukemia cells.

SGD-1882

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Catalog No. T19560Alias SGD1882, PBD dimerCas No. 1222490-34-7

SGD-1882 (PBD dimer) is a cytotoxic conjugate that is a target for mouse and human hematopoietic stem cells (HSC) and acute myeloid leukemia cells.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$1,264	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	SGD-1882 (PBD dimer) is a cytotoxic conjugate that is a target for mouse and human hematopoietic stem cells (HSC) and acute myeloid leukemia cells.
Targets&IC50	AML cells 3:0.25 pM, AML cells 2:0.22 pM, SHI cells:0.28 pM, A704 cells:9.85 pM, HepG2 cells:121 pM, AML cells 5:0.14 pM, HL-60 cells:1.58 pM
In vitro	SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I. [2]
Synonyms	SGD1882, PBD dimer

Chemical Properties

Molecular Weight	725.79
Formula	C₄₂H₃₉N₅O₇
Cas No.	1222490-34-7
Smiles	O=C1N2[C@@](CC(=C2)C3=CC=C(OC)C=C3)(C=NC=4C1=CC(OC)=C(OCCCOC5=C(OC)C=C6C(=C5)N=C[C@]7(N(C6=O)C=C(C7)C8=CC=C(N)C=C8)[H])C4)[H]
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (110.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3778 mL	6.8890 mL	13.7781 mL	68.8905 mL
5 mM	0.2756 mL	1.3778 mL	2.7556 mL	13.7781 mL
10 mM	0.1378 mL	0.6889 mL	1.3778 mL	6.8890 mL
20 mM	0.0689 mL	0.3445 mL	0.6889 mL	3.4445 mL
50 mM	0.0276 mL	0.1378 mL	0.2756 mL	1.3778 mL
100 mM	0.0138 mL	0.0689 mL	0.1378 mL	0.6889 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc