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Cpd27

Name: Cpd27
Brand: TargetMol
SKU: T40581
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40581Cas No. 501693-48-7

Alias TIE-2/VEGFR-2 kinase-IN-2

Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and protects RGCs from TNF-stimulated cell death and can be used to study glaucoma.

Cpd27

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Purity: 98.89%

Catalog No. T40581Alias TIE-2/VEGFR-2 kinase-IN-2Cas No. 501693-48-7

Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and protects RGCs from TNF-stimulated cell death and can be used to study glaucoma.

Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$139	In Stock
10 mg	$228	In Stock
25 mg	$459	In Stock
50 mg	$677	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Batch Information

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Purity:98.89%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and protects RGCs from TNF-stimulated cell death and can be used to study glaucoma.
Targets&IC50	Tie2:8.56 nM (pIC50)
Synonyms	TIE-2/VEGFR-2 kinase-IN-2

Chemical Properties

Molecular Weight	431.34
Formula	C₂₀H₁₃F₄N₅O₂
Cas No.	501693-48-7
Smiles	O=C(NC=1C=CC(=CC1)C2=COC3=NC=NC(N)=C32)NC4=CC(=CC=C4F)C(F)(F)F
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (92.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3184 mL	11.5918 mL	23.1836 mL	115.9178 mL
5 mM	0.4637 mL	2.3184 mL	4.6367 mL	23.1836 mL
10 mM	0.2318 mL	1.1592 mL	2.3184 mL	11.5918 mL
20 mM	0.1159 mL	0.5796 mL	1.1592 mL	5.7959 mL
50 mM	0.0464 mL	0.2318 mL	0.4637 mL	2.3184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc