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Anti-RIN1 Polyclonal Antibody

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Catalog No. TMAB-12258

Anti-RIN1 Polyclonal Antibody is a Rabbit antibody targeting RIN1. Anti-RIN1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-RIN1 Polyclonal Antibody

Anti-RIN1 Polyclonal Antibody

😃Good
Catalog No. TMAB-12258
Anti-RIN1 Polyclonal Antibody is a Rabbit antibody targeting RIN1. Anti-RIN1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2237-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5287-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-RIN1 Polyclonal Antibody is a Rabbit antibody targeting RIN1. Anti-RIN1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Rat (predicted:Human,Mouse,Pig,Cow)
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.
Tissue SpecificityExpressed in all tissues examined with high levels in brain, placenta and pancreas.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundRIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human RIN1
Antigen Species
Human
Gene Name
RIN1
Gene ID
Protein Name
Ras and Rab interactor 1
Uniprot ID
Function
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Chemical Properties
Molecular WeightTheoretical: 84 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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