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Stafib-1

Name: Stafib-1
Brand: TargetMol
SKU: T24838
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24838Cas No. 1688703-26-5

Alias Stafib1, Stafib 1

Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.

Stafib-1

🥰Excellent

Purity: 97.18%

Catalog No. T24838Alias Stafib1, Stafib 1Cas No. 1688703-26-5

Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$54	-	In Stock
5 mg	$129	-	In Stock
10 mg	$198	-	In Stock
25 mg	$378	-	In Stock
50 mg	$562	-	In Stock
1 mL x 10 mM (in DMSO)	$169	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.18%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.
Targets&IC50	STAT5b:154 nM (IC50)
In vitro	Stafib-1 inhibits STAT5β with more than 50-fold selectivity over STAT5a[2].
Synonyms	Stafib1, Stafib 1

Chemical Properties

Molecular Weight	602.42
Formula	C₂₆H₂₄N₂O₁₁P₂
Cas No.	1688703-26-5
Smiles	O(P(=O)(O)O)C1=C(OP(=O)(O)O)C=CC(CNC(COC2=CC3=C(C=C2)C=C(C(NC4=CC=CC=C4)=O)C=C3)=O)=C1
Relative Density.	1.587 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (157.70 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6600 mL	8.2999 mL	16.5997 mL	82.9986 mL
5 mM	0.3320 mL	1.6600 mL	3.3199 mL	16.5997 mL
10 mM	0.1660 mL	0.8300 mL	1.6600 mL	8.2999 mL
20 mM	0.0830 mL	0.4150 mL	0.8300 mL	4.1499 mL
50 mM	0.0332 mL	0.1660 mL	0.3320 mL	1.6600 mL
100 mM	0.0166 mL	0.0830 mL	0.1660 mL	0.8300 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc