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DNA Damage/DNA RepairCRISPR/Cas9
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome.
Brefeldin A
Cited
T606220350-15-6
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activity.
- $34
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CitedNocodazole Cited
T280231430-18-9
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.
- $31
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CitedBRD20322
T696452414154-84-8
BRD20322 is a novel potent inhibitor of spCas9 that disrupts spCas9-DNA binding and exerts dose and temporal control of spCas9 in human cell lines. It reduces off-target DNA editing events, enhancing the precision and safety of CRISPR-Cas9 gene editing.
- $545
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QTY
KU-57788
Cited
T6276503468-95-9
NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).
- $34
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CitedBRD0539
T222791403838-79-8
BRD0539 is a cell-permeable spCas9 inhibitor that blocks the binding of spCas9 to DNA and inhibits Streptococcus pyogenes Cas9 (SpCas9).
- $199
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Zidovudine Cited
T141630516-87-1
Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines.
- $44
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CitedRS-1
T6972312756-74-4
RS-1 is a RAD51 activator. RS-1 also increases CRISPR Cas9-mediated knock-in efficiencies.
- $32
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SCR7 pyrazine
T172414892-97-8
SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).
- $33
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L755507
T6872159182-43-1
L755507 is an effective, selective agonist of β3-AR(IC50=35 nM).
- $45
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BRD7586
T73444895460-70-5
BRD7586 is a cell-permeable small molecule inhibitor of SpCas9 that enhances SpCas9 specificity.
- $48
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(iso)-BRD20322
T69645L2986118-54-9
(iso)-BRD20322 is an isomer of BRD20322, a novel potent inhibitor of spCas9 that disrupts the binding of spCas9 to DNA and reduces non-specific DNA editing events, thereby improving the safety and accuracy of the CRISPR-Cas9 gene editing system.
- $195
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SCR7
T33401533426-72-0
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
- $185
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Cas9-IN-1
T62736
Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM, acting by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.
- $1,520
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9A1P9
T846402760467-57-8
9A1P9, a multi-tail ionizable cationic phospholipid, facilitates membrane destabilization and is applicable for CRISPR-Cas9 gene editing in mice [1].
- Inquiry Price
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Cas9-IN-2
T631261030133-34-6
Cas9-IN-2 is a potent Cas9 inhibitor with an IC50 of 246 μM. It binds to apo-Cas9, thereby preventing the formation of Cas9:gRNA complexes. Cas9-IN-2 can be used to regulate and control Cas9 activity.
- $1,520
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CEM114
T398102279062-54-1
CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM). It functions by employing CRISPR-Cas9 systems to harness endogenous chromatin machinery, thereby exerting its epigenetic modifying effects.
- $1,520
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Mca-VDQVDGW-Lys(Dnp)-NH2
T76268
Mca-VDQVDGW-Lys(Dnp)-NH2, a fluorogenic substrate specific to caspase-7, facilitates the quantification of caspase-7 activity.
- Inquiry Price
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Cas9-IN-3
T605202322051-02-3
Cas9-IN-3 is a potent inhibitor of Cas9 with an IC50 of 28 μM. The CRISPR Cas systems have revolutionized gene editing in several species [1].
- $1,520
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