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Anti-LRRC33 Polyclonal Antibody

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Catalog No. TMAB-08414

Anti-LRRC33 Polyclonal Antibody is a Rabbit antibody targeting LRRC33. Anti-LRRC33 Polyclonal Antibody can be used in WB.

Anti-LRRC33 Polyclonal Antibody

Anti-LRRC33 Polyclonal Antibody

😃Good
Catalog No. TMAB-08414
Anti-LRRC33 Polyclonal Antibody is a Rabbit antibody targeting LRRC33. Anti-LRRC33 Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-LRRC33 Polyclonal Antibody is a Rabbit antibody targeting LRRC33. Anti-LRRC33 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Mouse
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationMembrane; Single pass type I membrane protein.
Tissue SpecificityUbiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundLRRC33 is a 692 amino acid protein that contains 17 LRR repeats. The gene encoding LRRC33 maps to chromosome 3, which encodes over 1,100 genes. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Marfan syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
Antigen Details
Immunogen
Recombinant Protein: mouse LRRC33 protein
Antigen Species
Mouse
Gene Name
NRROS
Gene ID
Protein Name
Transforming growth factor beta activator LRRC33
Uniprot ID
Function
Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex.
May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.
Chemical Properties
Molecular WeightTheoretical: 74 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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