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Anti-LRRC33 Polyclonal Antibody
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Catalog No. TMAB-08414 Copy Product Info
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Anti-LRRC33 Polyclonal Antibody is a Rabbit antibody targeting LRRC33. Anti-LRRC33 Polyclonal Antibody can be used in WB.
Anti-LRRC33 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $220 | 7-10 days | 7-10 days | |
| 100 µL | $374 | 7-10 days | 7-10 days | |
| 200 µL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-LRRC33 Polyclonal Antibody is a Rabbit antibody targeting LRRC33. Anti-LRRC33 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse |
| Verified Activity | 25 μg total protein per lane of various lysates (see on figure) probed with LRRC33 polyclonal antibody, unconjugated (TMAB-08414) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single pass type I membrane protein. |
| Tissue Specificity | Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | LRRC33 is a 692 amino acid protein that contains 17 LRR repeats. The gene encoding LRRC33 maps to chromosome 3, which encodes over 1,100 genes. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Marfan syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3. |
| Immunogen | Recombinant Protein: mouse LRRC33 protein |
| Antigen Species | Mouse |
| Gene Name | NRROS |
| Gene ID | |
| Protein Name | Transforming growth factor beta activator LRRC33 |
| Uniprot ID | |
| Function | Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex.
May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production. |
| Molecular Weight | Theoretical: 74 kDa. Actual: 95 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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