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Synonyms: secreted phosphoprotein 1, OPN, ETA-1, BSPI, BNSP
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
| Description | Anti-Osteopontin Polyclonal Antibody is a Rabbit antibody targeting Osteopontin. Anti-Osteopontin Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | secreted phosphoprotein 1, OPN, ETA-1, BSPI, BNSP |
| Ig Type | IgG |
| Reactivity | Human,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:500-2000; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1ug/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Bone. Found in plasma. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Osteopontin is the principal phosphorylated glycoprotein of bone and is expressed in a limited number of other tissues including dentine. Osteopontin is produced by osteoblasts under stimulation by calcitriol and binds tightly to hydroxyapatite. It is also involved in the anchoring of osteoclasts to the mineral of bone matrix via the vitronectin receptor, which has specificity for osteopontin. Osteopontin is overexpressed in a variety of cancers, including lung, breast, colorectal, stomach, ovarian, melanoma and mesothelioma. |
| Immunogen | KLH conjugated synthetic peptide: human OPN |
| Antigen Species | Human |
| Gene Name | SPP1 |
| Gene ID | |
| Protein Name | Osteopontin |
| Uniprot ID | |
| Function | Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity). |
| Molecular Weight | Theoretical: 34 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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