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Seralutinib

Name: Seralutinib
Brand: TargetMol
SKU: T8900
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8900Cas No. 1619931-27-9

Alias GB002

Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.

Seralutinib

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Purity: 99.09%

Catalog No. T8900Alias GB002Cas No. 1619931-27-9

Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.

Pack Size	Price	Availability
1 mg	$42	In Stock
2 mg	$59	In Stock
5 mg	$98	In Stock
10 mg	$147	In Stock
25 mg	$263	In Stock
50 mg	$347	In Stock
100 mg	$553	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Batch Information

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Purity:99.09%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.
Targets&IC50	c-Kit:14 nM, CSF1R:8 nM
In vivo	GB002 dose- and time-dependently induces lung BMPR2 protein expression.GB002-mediated inhibition of lung PDGFRα/β phosphorylation in healthy Sprague Dawley rats immediately post inhalation[1].
Synonyms	GB002

Chemical Properties

Molecular Weight	469.54
Formula	C₂₇H₂₇N₅O₃
Cas No.	1619931-27-9
Smiles	COc1ccc(cc1OC)-c1cncc(N[C@@H](C)c2cccc(NC(=O)c3cncc(C)c3)c2)n1
Relative Density.	1.252 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (212.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1297 mL	10.6487 mL	21.2974 mL	106.4872 mL
5 mM	0.4259 mL	2.1297 mL	4.2595 mL	21.2974 mL
10 mM	0.2130 mL	1.0649 mL	2.1297 mL	10.6487 mL
20 mM	0.1065 mL	0.5324 mL	1.0649 mL	5.3244 mL
50 mM	0.0426 mL	0.2130 mL	0.4259 mL	2.1297 mL
100 mM	0.0213 mL	0.1065 mL	0.2130 mL	1.0649 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc