Shopping Cart

Your shopping cart is currently empty

LSN3318839

Name: LSN3318839
Brand: TargetMol
SKU: T63166
Price: 213 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Hot

Catalog No. T63166Cas No. 2764704-18-7

Alias LSN-3318839, LSN 3318839

LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can be used to lower blood glucose.

LSN3318839

Copy Product Info

🥰Excellent

Hot

Purity: 99.70%

Catalog No. T63166Alias LSN-3318839, LSN 3318839Cas No. 2764704-18-7

LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can be used to lower blood glucose.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$213	In Stock	In Stock
5 mg	$538	In Stock	In Stock
10 mg	$777	In Stock	In Stock
25 mg	$1,180	In Stock	In Stock
50 mg	$1,590	In Stock	In Stock
100 mg	$2,170	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.70%

ee:97.96%

Appearance:Solid

Color:Yellow

Resource Download

COA CSFC HNMR LCMS

Product Introduction

LSN3318839 AI Summary

LSN3318839 exhibits various bioactivities and pharmacokinetic properties. It functions as a positive allosteric modulator of the human GLP-1R, significantly increasing GLP-1(9-36) induced cAMP accumulation. Additionally, it acts as an agonist, with low EC50 values, for the GLP-1R by potentiating GLP-1(7-36) induced cAMP accumulation. It also shows partial agonist activity, moderately potentiating GLP-1(9-36) induced cAMP accumulation. This compound demonstrates anti-hyperglycemic activity in overnight-fasted GIPR KO C57BL/6 mice, effectively reducing blood glucose AUC at various doses and when used in combination with sitagliptin. It exhibits oral bioavailability and has been characterized by pharmacokinetic parameters such as clearance, half-life, volume of distribution, Cmax, and Tmax in different animal models..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can be used to lower blood glucose.
Synonyms	LSN-3318839, LSN 3318839

Chemical Properties

Molecular Weight	480.39
Formula	C₂₆H₂₃Cl₂N₃O₂
Cas No.	2764704-18-7
Smiles	[C@H](C)(N1C=2C(N=C1)=CN=C(C2)C3=C([C@H](C(O)=O)C)C=CC=C3)C4=C(Cl)C(=CC=C4Cl)C5CC5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (530.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0816 mL	10.4082 mL	20.8164 mL	104.0821 mL
5 mM	0.4163 mL	2.0816 mL	4.1633 mL	20.8164 mL
10 mM	0.2082 mL	1.0408 mL	2.0816 mL	10.4082 mL
20 mM	0.1041 mL	0.5204 mL	1.0408 mL	5.2041 mL
50 mM	0.0416 mL	0.2082 mL	0.4163 mL	2.0816 mL
100 mM	0.0208 mL	0.1041 mL	0.2082 mL	1.0408 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc