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Borrelidin

Name: Borrelidin
Brand: TargetMol
SKU: T10582
Rating: 4.5 (1 reviews)

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Catalog No. T10582Cas No. 7184-60-3

Alias Treponemycin

Borrelidin (Treponemycin) is a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei, which inhibits sugar-acyl-tRNA synthetase. It exhibits anticancer, antifungal, and anti-angiogenesis activities, inhibiting tumor growth and lung metastasis.

Borrelidin

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Catalog No. T10582Alias TreponemycinCas No. 7184-60-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 μg	$198	35 days	35 days
1 mg	$297	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Borrelidin (Treponemycin) is a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei, which inhibits sugar-acyl-tRNA synthetase. It exhibits anticancer, antifungal, and anti-angiogenesis activities, inhibiting tumor growth and lung metastasis.
Targets&IC50	CDC28-Cln2:24 μM
In vitro	Borrelidin can effectively inhibit the proliferation of ALL cell lines with a maximum 50% inhibitory concentration of 50 ng/mL. [1] The 50% inhibitory concentration (IC50) of Borrelidin for Cdc28/Cln2 was 24 μM. Borrelidin is a potent angiogenesis inhibitor with an IC50 value of 0.8 nM that induces apoptosis in angioforming cells. [3] Borrelidin showed highly selective cytotoxicity to cancer cells and endothelial cell subpopulations. [4]
In vivo	Borrelidin (0.25 mg/kg intraperitoneally injected) in combination with fumagilin increased antimalarial activity in Plasmodium berghei-infected mice. [5]
Synonyms	Treponemycin

Chemical Properties

Molecular Weight	489.64
Formula	C₂₈H₄₃NO₆
Cas No.	7184-60-3
Smiles	C[C@H]1C[C@H](C[C@@H]([C@H](/C(=C\C=C\C[C@H](OC(=O)C[C@@H]([C@H](C1)C)O)[C@@H]2CCC[C@H]2C(=O)O)/C#N)O)C)C
Relative Density.	1.1362 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 100 mg/mL (204.23 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.0423 mL	10.2116 mL	20.4232 mL	102.1158 mL
5 mM	0.4085 mL	2.0423 mL	4.0846 mL	20.4232 mL
10 mM	0.2042 mL	1.0212 mL	2.0423 mL	10.2116 mL
20 mM	0.1021 mL	0.5106 mL	1.0212 mL	5.1058 mL
50 mM	0.0408 mL	0.2042 mL	0.4085 mL	2.0423 mL
100 mM	0.0204 mL	0.1021 mL	0.2042 mL	1.0212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc