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Borrelidin

Name: Borrelidin
Brand: TargetMol
SKU: T10582
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10582Cas No. 7184-60-3

Alias Treponemycin

Borrelidin (Treponemycin) is a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei, which inhibits sugar-acyl-tRNA synthetase. It exhibits anticancer, antifungal, and anti-angiogenesis activities, inhibiting tumor growth and lung metastasis.

Borrelidin

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Catalog No. T10582Alias TreponemycinCas No. 7184-60-3

Pack Size	Price	Availability	Quantity
500 μg	$198	In Stock
1 mg	$297	35 days

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Product Introduction

Bioactivity

Description	Borrelidin (Treponemycin) is a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei, which inhibits sugar-acyl-tRNA synthetase. It exhibits anticancer, antifungal, and anti-angiogenesis activities, inhibiting tumor growth and lung metastasis.
Targets&IC50	CDC28-Cln2:24 μM
In vitro	Borrelidin can effectively inhibit the proliferation of ALL cell lines with a maximum 50% inhibitory concentration of 50 ng/mL. [1] The 50% inhibitory concentration (IC50) of Borrelidin for Cdc28/Cln2 was 24 μM. Borrelidin is a potent angiogenesis inhibitor with an IC50 value of 0.8 nM that induces apoptosis in angioforming cells. [3] Borrelidin showed highly selective cytotoxicity to cancer cells and endothelial cell subpopulations. [4]
In vivo	Borrelidin (0.25 mg/kg intraperitoneally injected) in combination with fumagilin increased antimalarial activity in Plasmodium berghei-infected mice. [5]
Synonyms	Treponemycin

Chemical Properties

Molecular Weight	489.64
Formula	C₂₈H₄₃NO₆
Cas No.	7184-60-3
Smiles	C[C@H]1C[C@H](C[C@@H]([C@H](/C(=C\C=C\C[C@H](OC(=O)C[C@@H]([C@H](C1)C)O)[C@@H]2CCC[C@H]2C(=O)O)/C#N)O)C)C
Relative Density.	1.1362 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 100 mg/mL (204.23 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.0423 mL	10.2116 mL	20.4232 mL	102.1158 mL
5 mM	0.4085 mL	2.0423 mL	4.0846 mL	20.4232 mL
10 mM	0.2042 mL	1.0212 mL	2.0423 mL	10.2116 mL
20 mM	0.1021 mL	0.5106 mL	1.0212 mL	5.1058 mL
50 mM	0.0408 mL	0.2042 mL	0.4085 mL	2.0423 mL
100 mM	0.0204 mL	0.1021 mL	0.2042 mL	1.0212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc