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Tolonidine

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Catalog No. T17113Cas No. 4201-22-3

Tolonidine (2-(2-chloro-p-toluidino)-2-imidazoline nitrate) is a potent antihypertensive agent that functions as an alpha-adrenergic receptor agonist. Structurally related to clonidine, it modulates the circulatory system by acting on central and peripheral alpha-adrenergic receptors. It effectively reduces blood pressure and peripheral vascular resistance while influencing cardiac contraction and circulatory parameters. Studies also indicate that Tolonidine modulates autonomic receptor activity and promotes diuresis.

Tolonidine

Tolonidine

😃Good
Catalog No. T17113Cas No. 4201-22-3
Tolonidine (2-(2-chloro-p-toluidino)-2-imidazoline nitrate) is a potent antihypertensive agent that functions as an alpha-adrenergic receptor agonist. Structurally related to clonidine, it modulates the circulatory system by acting on central and peripheral alpha-adrenergic receptors. It effectively reduces blood pressure and peripheral vascular resistance while influencing cardiac contraction and circulatory parameters. Studies also indicate that Tolonidine modulates autonomic receptor activity and promotes diuresis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$50-In Stock
5 mg$113-In Stock
10 mgPreferential-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Tolonidine (2-(2-chloro-p-toluidino)-2-imidazoline nitrate) is a potent antihypertensive agent that functions as an alpha-adrenergic receptor agonist. Structurally related to clonidine, it modulates the circulatory system by acting on central and peripheral alpha-adrenergic receptors. It effectively reduces blood pressure and peripheral vascular resistance while influencing cardiac contraction and circulatory parameters. Studies also indicate that Tolonidine modulates autonomic receptor activity and promotes diuresis.
Chemical Properties
Molecular Weight209.68
FormulaC10H12ClN3
Cas No.4201-22-3
SmilesClC1=CC(=CC=C1NC2=NCCN2)C
Relative Density.1.31 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (381.53 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.7692 mL23.8459 mL47.6917 mL238.4586 mL
5 mM0.9538 mL4.7692 mL9.5383 mL47.6917 mL
10 mM0.4769 mL2.3846 mL4.7692 mL23.8459 mL
20 mM0.2385 mL1.1923 mL2.3846 mL11.9229 mL
50 mM0.0954 mL0.4769 mL0.9538 mL4.7692 mL
100 mM0.0477 mL0.2385 mL0.4769 mL2.3846 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tolonidine
Related Tags: buy Tolonidine | purchase Tolonidine | Tolonidine cost | order Tolonidine | Tolonidine chemical structure | Tolonidine formula | Tolonidine molecular weight
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