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NRP1 antagonist 1

Name: NRP1 antagonist 1
Brand: TargetMol
SKU: T62727
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T62727Cas No. 2569598-01-0

NRP1 antagonist 1 is a potent and non-peptide NRP1 antagonist with IC50=19.1 μM that has anti-tumor potential by blocking VEGF-NRP interactions.

NRP1 antagonist 1

🥰Excellent

Catalog No. T62727Cas No. 2569598-01-0

NRP1 antagonist 1 is a potent and non-peptide NRP1 antagonist with IC50=19.1 μM that has anti-tumor potential by blocking VEGF-NRP interactions.

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Product Introduction

Bioactivity

Description

NRP1 antagonist 1 is a potent and non-peptide NRP1 antagonist with IC50=19.1 μM that has anti-tumor potential by blocking VEGF-NRP interactions.

Chemical Properties

Molecular Weight	450.58
Formula	C₂₂H₂₂N₆OS₂
Cas No.	2569598-01-0
Smiles	O=C(NC1=NN=C(S1)CC)CSC2=NN=C(C=3C=CC(=CC3)C)N2C4=CC=CC(=C4)C
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (110.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2194 mL	11.0968 mL	22.1936 mL	110.9681 mL
5 mM	0.4439 mL	2.2194 mL	4.4387 mL	22.1936 mL
10 mM	0.2219 mL	1.1097 mL	2.2194 mL	11.0968 mL
20 mM	0.1110 mL	0.5548 mL	1.1097 mL	5.5484 mL
50 mM	0.0444 mL	0.2219 mL	0.4439 mL	2.2194 mL
100 mM	0.0222 mL	0.1110 mL	0.2219 mL	1.1097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc