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PCC0208009

Name: PCC0208009
Brand: TargetMol
SKU: T4142
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4142Cas No. 1668565-74-9

Alias IDO-IN-2, IDO inhibitor 1, DO-IN-2

PCC0208009 (IDO-IN-2) is an IDO inhibitor.

PCC0208009

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Purity: 99.89%

Catalog No. T4142Alias IDO-IN-2, IDO inhibitor 1, DO-IN-2Cas No. 1668565-74-9

PCC0208009 (IDO-IN-2) is an IDO inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
2 mg	$54	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$153	In Stock	In Stock
25 mg	$286	In Stock	In Stock
50 mg	$488	In Stock	In Stock
100 mg	$673	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

PCC0208009 AI Summary

PCC0208009 inhibits IDO1 in IFN-gamma stimulated human HeLa cells by reducing kynurenine production, with an IC50 value of 4.0 nM. This compound also exhibits strong IDO1 inhibition in human HeLa cells with an IC50 of 7.0 nM and poor inhibition of TDO in HEK cells with an IC50 greater than 7500.0 nM. It shows moderate metabolic stability in various liver microsomes and demonstrates a transactivation of PXR with an EC50 of 1400.0 nM and an Emax of 110.0% relative to the control. Additionally, PCC0208009 inhibits multiple human CYP enzymes, including CYP2C9, CYP1A2, CYP2C19, CYP2D6, CYP3A4, CYP2C8, and CYP2B6, with varying IC50 values and displays species-dependent stability in liver microsomes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PCC0208009 (IDO-IN-2) is an IDO inhibitor.
Targets&IC50	IDO:3 nM
Synonyms	IDO-IN-2, IDO inhibitor 1, DO-IN-2

Chemical Properties

Molecular Weight	497.63
Formula	C₂₉H₃₅N₇O
Cas No.	1668565-74-9
Smiles	CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(C)cc1)-c1ccccc1-c1nn[nH]n1
Relative Density.	1.206 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (120.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0095 mL	10.0476 mL	20.0953 mL	100.4763 mL
5 mM	0.4019 mL	2.0095 mL	4.0191 mL	20.0953 mL
10 mM	0.2010 mL	1.0048 mL	2.0095 mL	10.0476 mL
20 mM	0.1005 mL	0.5024 mL	1.0048 mL	5.0238 mL
50 mM	0.0402 mL	0.2010 mL	0.4019 mL	2.0095 mL
100 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0048 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc