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Iclepertin

🥰Excellent
Catalog No. T37089Cas No. 1421936-85-7
Alias BI-425809

Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer;s disease. Iclepertin is used for central nervous system disorders such as Alzheimer;s disease, schizophrenia and cognitive disorders.

Iclepertin

Iclepertin

🥰Excellent
Purity: 98.93%
Catalog No. T37089Alias BI-425809Cas No. 1421936-85-7
Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer;s disease. Iclepertin is used for central nervous system disorders such as Alzheimer;s disease, schizophrenia and cognitive disorders.
Pack SizePriceAvailabilityQuantity
1 mg$97In Stock
2 mg$123In Stock
5 mg$172In Stock
10 mg$235In Stock
25 mg$387In Stock
50 mg$581In Stock
100 mg$870In Stock
200 mg$1,170In Stock
1 mL x 10 mM (in DMSO)$193In Stock
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Purity:98.93%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer;s disease. Iclepertin is used for central nervous system disorders such as Alzheimer;s disease, schizophrenia and cognitive disorders.
Targets&IC50
GLT1:5.2 mM (rat primary neurons), GLT1:5 nM (human SK-N-MC cells)
In vitro
As an inhibitor of GlyT1, Iclepertin has IC50 values of 5.2 nM and 5.0 nM in primary rat neurons and human SK-N-MC cells, respectively[1].
In vivo
In rats, oral administration of Iclepertin (BI 425809) induces a dose-dependent increase in cerebrospinal fluid levels of glycine from 30% (0.2 mg/kg) to 78% (2 mg/kg)[1].
SynonymsBI-425809
Chemical Properties
Molecular Weight512.42
FormulaC20H18F6N2O5S
Cas No.1421936-85-7
Smiles[H][C@@]12C[C@@]1(CN(C2)C(=O)c1cc(ccc1O[C@H](C)C(F)(F)F)S(C)(=O)=O)c1cc(on1)C(F)(F)F
Relative Density.1.508 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

IclepertinGlyT1
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