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Ambenonium

Name: Ambenonium
Brand: TargetMol
SKU: T71758
Rating: 4.5 (1 reviews)

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Catalog No. T71758Cas No. 7648-98-8

Alias WIN8077, WIN 8077

Ambenonium (WIN 8077) is a competitive and reversible cholinesterase AChE inhibitor with the advantage of being orally available with an IC50 = 0.7 nM for the treatment of myasthenia gravis.

Ambenonium

😃Good

Catalog No. T71758Alias WIN8077, WIN 8077Cas No. 7648-98-8

Ambenonium (WIN 8077) is a competitive and reversible cholinesterase AChE inhibitor with the advantage of being orally available with an IC50 = 0.7 nM for the treatment of myasthenia gravis.

Pack Size	Price	Availability
1 mg	$293	6-8 weeks
5 mg	$722	6-8 weeks
10 mg	$987	6-8 weeks
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Ambenonium (WIN 8077) is a competitive and reversible cholinesterase AChE inhibitor with the advantage of being orally available with an IC50 = 0.7 nM for the treatment of myasthenia gravis.
Targets&IC50	BChE (human):8.2  μM, AChE (human):0.0007  μM
In vitro	Ambenonium inhibited human AChE with high potency (IC₅₀ = 0.0007 μM; Ellman’s method; 20 min incubation), and showed strong selectivity over BChE (IC₅₀ = 8.2 μM)[1].
Alias	WIN8077, WIN 8077

Chemical Properties

Molecular Weight	537.57
Formula	C₂₈H₄₂Cl₂N₄O₂
Cas No.	7648-98-8
Smiles	O=C(NCC[N+](CC=1C=CC=CC1Cl)(CC)CC)C(=O)NCC[N+](CC=2C=CC=CC2Cl)(CC)CC

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MytelaseMisuranAmbestigmin chlorideAmbenonium dichlorideAmbenonium ChlorideAmbenonii chloridum