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Stavudine

Stavudine
Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
Catalog No. T1404Cas No. 3056-17-5
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Purity:100%
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Stavudine

Catalog No. T1404Cas No. 3056-17-5

Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
50 mg$33In Stock
100 mg$47In Stock
200 mg$65In Stock
500 mg$97In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
In vitro
In lean mice, Stavudine (500 mg/kg/day) reduces mitochondrial DNA in the liver and muscle, inducing ketoacidosis during fasting periods. In obese mice, Stavudine (500 mg/kg/day) depletes mtDNA in White Adipose Tissue (WAT).
In vivo
Stavudine reduces lipid content and influences the expression of lipid metabolism markers, such as C/EBPα, peroxisome proliferator-activated receptor γ, adipocyte lipid-binding protein 2, fatty acid synthase, and acetyl-CoA carboxylase. In 3T3-F442A cells, Stavudine induces apoptosis and reduces both lipid content and viability in 3T3-L1 adipocytes. Furthermore, in peripheral blood mononuclear cells (PBMC), Stavudine inhibits the production of p24 antigen by HIV-1, with an effective dose range of 0.04 μM to 0.2 μM (ED50 = 0.04 μM-0.2 μM).
Aliasd4T, Sanilvudine, BMY-27857, NSC 163661
Chemical Properties
Molecular Weight224.21
FormulaC10H12N2O4
Cas No.3056-17-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (223.01 mM)
H2O: 22.4 mg/mL (100 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM4.4601 mL22.3005 mL44.6010 mL223.0052 mL
5 mM0.8920 mL4.4601 mL8.9202 mL44.6010 mL
10 mM0.4460 mL2.2301 mL4.4601 mL22.3005 mL
20 mM0.2230 mL1.1150 mL2.2301 mL11.1503 mL
50 mM0.0892 mL0.4460 mL0.8920 mL4.4601 mL
100 mM0.0446 mL0.2230 mL0.4460 mL2.2301 mL

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