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Riluzole

Name: Riluzole
Brand: TargetMol
SKU: T0349
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0349Cas No. 1744-22-5

Alias RP-54274, PK 26124

Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Riluzole

🥰Excellent

Purity: 99.88%

Catalog No. T0349Alias RP-54274, PK 26124Cas No. 1744-22-5

Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Pack Size	Price	Availability
25 mg	$33	In Stock
50 mg	$45	In Stock
100 mg	$58	In Stock
500 mg	$117	In Stock
1 g	$157	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:99.88%

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Product Introduction

Bioactivity

Description	Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Targets&IC50	GABA:43 μM
In vitro	Riluzole readily crosses the blood-brain barrier. Treatment of rodents with transient cerebral ischemia with 8 mg/kg i.p. Riluzole completely inhibited the massive release of glutamic acid induced by local ischemia.
In vivo	Riluzole readily crosses the blood-brain barrier. Treatment of rodents with transient cerebral ischemia with 8 mg/kg i.p. Riluzole completely inhibited the massive release of glutamic acid induced by local ischemia.
Synonyms	RP-54274, PK 26124

Chemical Properties

Molecular Weight	234.2
Formula	C₈H₅F₃N₂OS
Cas No.	1744-22-5
Smiles	NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2
Relative Density.	1.572 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (1024.77 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 43 mg/mL (183.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (21.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2699 mL	21.3493 mL	42.6985 mL	213.4927 mL
5 mM	0.8540 mL	4.2699 mL	8.5397 mL	42.6985 mL
10 mM	0.4270 mL	2.1349 mL	4.2699 mL	21.3493 mL
20 mM	0.2135 mL	1.0675 mL	2.1349 mL	10.6746 mL
50 mM	0.0854 mL	0.4270 mL	0.8540 mL	4.2699 mL
100 mM	0.0427 mL	0.2135 mL	0.4270 mL	2.1349 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc