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SK-575

Name: SK-575
Brand: TargetMol
SKU: T69596
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69596Cas No. 2523016-96-6

SK-575 is a degradation agent targeting protein-hydrolyzed PARP1 chimera with anticancer and antitumor activity.SK-575 effectively inhibits the growth of cancer cells harboring BRCA1/2 mutations and selectively induces PARP1 degradation in cancer cells.

SK-575

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Purity: 99.39%

Catalog No. T69596Cas No. 2523016-96-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$107	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$419	In Stock	In Stock
25 mg	$868	In Stock	In Stock
50 mg	$1,390	In Stock	In Stock
100 mg	$2,190	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.39%

Appearance:Solid

Color:Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	SK-575 is a degradation agent targeting protein-hydrolyzed PARP1 chimera with anticancer and antitumor activity.SK-575 effectively inhibits the growth of cancer cells harboring BRCA1/2 mutations and selectively induces PARP1 degradation in cancer cells.
Targets&IC50	PARP1 degradation activity:6.72 nM (in Capan-1 cells), PARP1 degradation activity:1.26 nM (in MDA-MB-436 cells), PARP1 degradation activity:0.509 nM (in SW620 cells)
In vitro	In MDA-MB-436, Capan-1, and SW620 cells, SK-575 (10000, 1000, 300, 100, 30, 10, 3, 1, 0.3, 0.1, 0.03, and 0.01 nM; 24 hours) exhibited significant PARP1 degradation activity, with IC50 values of 1.26, 6.72, and 0.509 nM, respectively[1].
In vivo	In male BALB/c nude mice bearing xenograft Capan-1 tumors, SK-575 (25 mg/kg, 50 mg/kg; intraperitoneal injection, once daily for 5 consecutive days) inhibited tumor growth. These doses of SK-575 (25 and 50 mg/kg) were well tolerated, with no observed mouse lethality or significant weight loss during the treatment period[1].

Chemical Properties

Molecular Weight	876.97
Formula	C₄₇H₅₃FN₈O₈
Cas No.	2523016-96-6
Smiles	O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CCN(C(=O)CCCCCCCCCCC(=O)NCCNC5=CC=CC=6C(=O)N(C(=O)C56)C7C(=O)NC(=O)CC7)CC4

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (91.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1403 mL	5.7014 mL	11.4029 mL	57.0145 mL
5 mM	0.2281 mL	1.1403 mL	2.2806 mL	11.4029 mL
10 mM	0.1140 mL	0.5701 mL	1.1403 mL	5.7014 mL
20 mM	0.0570 mL	0.2851 mL	0.5701 mL	2.8507 mL
50 mM	0.0228 mL	0.1140 mL	0.2281 mL	1.1403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc