NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc)

Catalog No. TMPJ-00097

NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 50-70 KDa and the accession number is P61252.

NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc)

Catalog No. TMPJ-00097

NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 50-70 KDa and the accession number is P61252.

Pack Size	Price	Availability
5 μg	$55	7-10 days
10 μg	$86	7-10 days
20 μg	$137	7-10 days
50 μg	$262	7-10 days
100 μg	$488	7-10 days
200 μg	$923	7-10 days
500 μg	$2,150	7-10 days
1 mg	$3,220	7-10 days

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Product Information

Biological Activity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 50-70 KDa and the accession number is P61252.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	N-hFc
Accession Number	P61252
Synonyms	NKG2-D-activating NK receptor,NKG2-D type II integral membrane protein,NKG2-D,NK cell receptor D,member 1,KLRK1,KLR,Killer cell lectin-like receptor subfamily K member 1,killer cell lectin-like receptor subfamily K,CD314 antigen,CD314
Amino Acid	Phe78-Val216
Construction	Phe78-Val216
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	50-70 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor, it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.