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Win 58237
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Catalog No. T13341Cas No. 158001-76-4
Win 58237 is an inhibitor of cyclic nucleotide phosphodiesterase (PDE) (Ki: 170 nM for PDE V), with vasorelaxant activity.
Win 58237
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Catalog No. T13341Cas No. 158001-76-4
Win 58237 is an inhibitor of cyclic nucleotide phosphodiesterase (PDE) (Ki: 170 nM for PDE V), with vasorelaxant activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Win 58237 is an inhibitor of cyclic nucleotide phosphodiesterase (PDE) (Ki: 170 nM for PDE V), with vasorelaxant activity. |
| Targets&IC50 | PDE5:ki:170 nM |
| In vitro | Win 58237 is a competitive cGMP PDE V inhibitor from canine aorta(Ki : 170 nM). Win 58237 is a potent PDE V inhibitor isolated from vascular tissue (IC50 : 240 nM). It is a relatively less potent calmodulin-sensitive PDE I and cGMP-inhibitable cyclic AMP PDE III inhibitor ; but does inhibit cyclic AMP PDE IV with an IC50 value of approximately 300 nM. Win 58237 possesses vasorelaxant activity in the presence of an intact endothelium or nitric oxide. |
| In vivo | In vivo administration of Win 58237, at dosages ranging from 0.3 to 3.0 mg/kg intravenously, reduces mean arterial pressure in conscious spontaneously hypertensive rats, accompanied by a rise in vascular (aortic) cGMP content. Additionally, at a higher dosage of 10 mg/kg intravenously, Win 58237 elevates plasma cGMP levels from a baseline of 6.7 ± 1.0 to 31.4 ± 3.5 fmol/μL. |
| Molecular Weight | 295.34 |
| Formula | C16H17N5O |
| Cas No. | 158001-76-4 |
| Smiles | CC=1C2=C(N(N1)C3CCCC3)NC(=NC2=O)C=4C=CN=CC4 |
| Relative Density. | 1.46 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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