store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JY-2 is an orally active and selective forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity and inhibits FoxO1 transcription.JY-2 can be used to study psoriasis and diabetes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 80.00 | |
25 mg | In stock | $ 163.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 372.00 |
Description | JY-2 is an orally active and selective forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity and inhibits FoxO1 transcription.JY-2 can be used to study psoriasis and diabetes. |
In vitro | JY-2, at concentrations ranging from 10 to 100 μM for 24 hours, reduces palmitic acid induced lipotoxicity in HepG2 and INS-1 cells [1]. |
In vivo | JY-2 exhibits anti-diabetic effects in mice, administered orally at doses of 50-200 mg/kg, either three times over two days or daily for 4 weeks [1]. |
Molecular Weight | 292.12 |
Formula | C13H7Cl2N3O |
CAS No. | 339103-05-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (273.86 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
JY-2 339103-05-8 Apoptosis FOXO1 inhibitor inhibit