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JY-2

Name: JY-2
Brand: TargetMol
SKU: T73578
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73578Cas No. 339103-05-8

JY-2 is an orally active and selective forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity and inhibits FoxO1 transcription.JY-2 can be used to study psoriasis and diabetes.

JY-2

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Purity: 99.91%

Catalog No. T73578Cas No. 339103-05-8

JY-2 is an orally active and selective forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity and inhibits FoxO1 transcription.JY-2 can be used to study psoriasis and diabetes.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$247	In Stock	In Stock
100 mg	$372	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	JY-2 is an orally active and selective forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity and inhibits FoxO1 transcription.JY-2 can be used to study psoriasis and diabetes.
In vitro	JY-2, at concentrations ranging from 10 to 100 μM for 24 hours, reduces palmitic acid induced lipotoxicity in HepG2 and INS-1 cells [1].
In vivo	JY-2 exhibits anti-diabetic effects in mice, administered orally at doses of 50-200 mg/kg, either three times over two days or daily for 4 weeks [1].

Chemical Properties

Molecular Weight	292.12
Formula	C₁₃H₇Cl₂N₃O
Cas No.	339103-05-8
Smiles	ClC1=CC(Cl)=C(C=C1)C1=NC(=NO1)C1=NC=CC=C1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (273.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4233 mL	17.1163 mL	34.2325 mL	171.1625 mL
5 mM	0.6847 mL	3.4233 mL	6.8465 mL	34.2325 mL
10 mM	0.3423 mL	1.7116 mL	3.4233 mL	17.1163 mL
20 mM	0.1712 mL	0.8558 mL	1.7116 mL	8.5581 mL
50 mM	0.0685 mL	0.3423 mL	0.6847 mL	3.4233 mL
100 mM	0.0342 mL	0.1712 mL	0.3423 mL	1.7116 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc