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Azacyclonol

Name: Azacyclonol
Brand: TargetMol
SKU: T0318
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0318Cas No. 115-46-8

Alias γ-pipradol, MER 17, MDL 4829, Ataractan

Azacyclonol (MER 17) is a drug used to diminish hallucinations in psychotic individuals.

Azacyclonol

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Purity: 99.46%

Catalog No. T0318Alias γ-pipradol, MER 17, MDL 4829, AtaractanCas No. 115-46-8

Azacyclonol (MER 17) is a drug used to diminish hallucinations in psychotic individuals.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.46%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Azacyclonol (MER 17) is a drug used to diminish hallucinations in psychotic individuals.
In vitro	Azacyclonol exhibits an inhibitory effect on the activity of feline cervical sympathetic ganglia by 6.63%. Intravenous injection of Azacyclonol modifies the nictitating membrane's response to postganglionic and preganglionic stimulation.
In vivo	Azacyclonol affects human hepatic microsomes with apparent Km and Vmax values of 0.82 μM and 60 pmol/min/mg, respectively. In human intestinal microsomes, the formation of azacyclonol is time-dependent, demonstrating linearity up to 60 minutes. The rate of azacyclonol formation increases linearly with microsomal protein concentrations reaching 2 mg/mL.
Synonyms	γ-pipradol, MER 17, MDL 4829, Ataractan

Chemical Properties

Molecular Weight	267.37
Formula	C₁₈H₂₁NO
Cas No.	115-46-8
Smiles	OC(C1CCNCC1)(C1=CC=CC=C1)C1=CC=CC=C1
Relative Density.	Ca. 1.103 g/cm3.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 49 mg/mL (183.27 mM), Sonication is recommended.

H2O: 2 mg/mL (7.48 mM), Sonication is recommended.

DMSO: 50 mg/mL (187.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7401 mL	18.7007 mL	37.4014 mL	187.0068 mL
5 mM	0.7480 mL	3.7401 mL	7.4803 mL	37.4014 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3740 mL	1.8701 mL	3.7401 mL	18.7007 mL
20 mM	0.1870 mL	0.9350 mL	1.8701 mL	9.3503 mL
50 mM	0.0748 mL	0.3740 mL	0.7480 mL	3.7401 mL
100 mM	0.0374 mL	0.1870 mL	0.3740 mL	1.8701 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc