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JNK-1-IN-3

🥰Excellent
Catalog No. T200221Cas No. 3056388-71-4

JNK-1-IN-3 (Compound 9e) is a JNK1 inhibitor that downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity. JNK-1-IN-3 exhibits potent antiproliferative activity against renal carcinoma and breast cancer cell lines.

JNK-1-IN-3

JNK-1-IN-3

🥰Excellent
Purity: 97.551%
Catalog No. T200221Cas No. 3056388-71-4
JNK-1-IN-3 (Compound 9e) is a JNK1 inhibitor that downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity. JNK-1-IN-3 exhibits potent antiproliferative activity against renal carcinoma and breast cancer cell lines.
Pack SizePriceAvailabilityQuantity
1 mg$96In Stock
5 mg$237In Stock
10 mg$378In Stock
25 mg$795In Stock
1 mL x 10 mM (in DMSO)$258In Stock
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Purity:97.551%
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Product Introduction

Bioactivity
Description
JNK-1-IN-3 (Compound 9e) is a JNK1 inhibitor that downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity. JNK-1-IN-3 exhibits potent antiproliferative activity against renal carcinoma and breast cancer cell lines.
Chemical Properties
Molecular Weight368.36
FormulaC19H17FN4O3
Cas No.3056388-71-4
SmilesO=C(NNC=1N=NC(=CC1)C2=CC=C(OC)C(OC)=C2)C3=CC=C(F)C=C3
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (217.18 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7147 mL13.5737 mL27.1474 mL135.7368 mL
5 mM0.5429 mL2.7147 mL5.4295 mL27.1474 mL
10 mM0.2715 mL1.3574 mL2.7147 mL13.5737 mL
20 mM0.1357 mL0.6787 mL1.3574 mL6.7868 mL
50 mM0.0543 mL0.2715 mL0.5429 mL2.7147 mL
100 mM0.0271 mL0.1357 mL0.2715 mL1.3574 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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