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NS 11021

Name: NS 11021
Brand: TargetMol
SKU: T4294
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4294Cas No. 956014-19-0

Alias NS11021

NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels

NS 11021

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Purity: 97.26%

Catalog No. T4294Alias NS11021Cas No. 956014-19-0

NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	-	In Stock
5 mg	$85	-	In Stock
10 mg	$137	-	In Stock
25 mg	$292	-	In Stock
50 mg	$496	-	In Stock
100 mg	$845	-	In Stock
200 mg	$1,130	-	In Stock
1 mL x 10 mM (in DMSO)	$96	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.26%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels
In vivo	NS11021 increased currents sensitive to the selective BK(Ca) channel blocker, iberiotoxin (IbTX) in SMCs, but did not modulate K(+) current in HUVECs.?NS11021 reduced [Ca(2+)](i) and tension in penile arteries.?IbTX inhibited the vasorelaxation induced by NS11021 and sildenafil in human erectile tissue.?NS11021 and sildenafil but not vehicle increased erectile responses in anaesthetized rats, an effect which was abolished after pretreatment with tetraethylammonium[1].
Synonyms	NS11021

Chemical Properties

Molecular Weight	511.24
Formula	C₁₆H₉BrF₆N₆S
Cas No.	956014-19-0
Smiles	FC(F)(F)c1cc(NC(=S)Nc2ccc(Br)cc2-c2nnn[nH]2)cc(c1)C(F)(F)F
Relative Density.	1.798±0.06 g/cm3(20 °C , 760mmHg)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (489.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9560 mL	9.7801 mL	19.5603 mL	97.8014 mL
5 mM	0.3912 mL	1.9560 mL	3.9121 mL	19.5603 mL
10 mM	0.1956 mL	0.9780 mL	1.9560 mL	9.7801 mL
20 mM	0.0978 mL	0.4890 mL	0.9780 mL	4.8901 mL
50 mM	0.0391 mL	0.1956 mL	0.3912 mL	1.9560 mL
100 mM	0.0196 mL	0.0978 mL	0.1956 mL	0.9780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc