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Anti-IL-13 Antibody (H2L6)
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Catalog No. T9901A-1317
Alias H2L6
Anti-IL-13 Antibody (H2L6) is a humanized monoclonal antibody specifically targeting human interleukin-13 (IL-13). The compound binds to IL-13 with high affinity, effectively blocking its interaction with the receptor complex (IL-13Ra1 and IL-4Ra), thereby inhibiting downstream signaling such as STAT6 phosphorylation. As IL-13 is a key driver of Th2-mediated immune responses, H2L6 is widely utilized in preclinical research for asthma, atopic dermatitis, and other allergic or inflammatory disorders.
Anti-IL-13 Antibody (H2L6)
Anti-IL-13 Antibody (H2L6)
Copy Product Info🥰Excellent
Catalog No. T9901A-1317Alias H2L6
Anti-IL-13 Antibody (H2L6) is a humanized monoclonal antibody specifically targeting human interleukin-13 (IL-13). The compound binds to IL-13 with high affinity, effectively blocking its interaction with the receptor complex (IL-13Ra1 and IL-4Ra), thereby inhibiting downstream signaling such as STAT6 phosphorylation. As IL-13 is a key driver of Th2-mediated immune responses, H2L6 is widely utilized in preclinical research for asthma, atopic dermatitis, and other allergic or inflammatory disorders.
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| Description | Anti-IL-13 Antibody (H2L6) is a humanized monoclonal antibody specifically targeting human interleukin-13 (IL-13). The compound binds to IL-13 with high affinity, effectively blocking its interaction with the receptor complex (IL-13Ra1 and IL-4Ra), thereby inhibiting downstream signaling such as STAT6 phosphorylation. As IL-13 is a key driver of Th2-mediated immune responses, H2L6 is widely utilized in preclinical research for asthma, atopic dermatitis, and other allergic or inflammatory disorders. |
| Targets&IC50 | IL-13:35 pM(Kd) |
| In vitro | In Surface Plasmon Resonance (SPR) assays, Anti-IL-13 Antibody (H2L6) exhibited a high affinity for human IL-13 with a KD of approximately 35 pM. In functional cell-based assays using TF-1 cells, H2L6 dose-dependently neutralized IL-13-induced STAT6 phosphorylation with an IC50 of approximately 46 pM [1]. |
| In vivo | In preclinical models of Th2-driven inflammation, systemic administration of Anti-IL-13 Antibody (H2L6) successfully inhibited IL-13-mediated biological effects, including the reduction of inflammatory cytokine release and attenuation of tissue eosinophilia, demonstrating its potential in managing allergic airway inflammation [1]. |
| Synonyms | H2L6 |
| Clone | H2L6 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | IL-13 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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