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Carotuximab
(Synonyms: TRC105, DE-122) Copy Product Info
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Synonyms: TRC105, DE-122
Catalog No. T76941 Copy Product Info
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Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia.
Cas No. 1268714-50-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $129 | - | In Stock | |
| 5 mg | $396 | - | In Stock | |
| 10 mg | $635 | - | In Stock | |
| 25 mg | $983 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
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Purity:> 95%
Appearance:Liquid
Color:Transparent
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| Description | Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia. |
| In vitro | In human aortic endothelial cells, pretreatment with Carotuximab (TRC105) at a concentration of 300 μg/mL for 1 hour, followed by co-culture for 12 hours, resulted in the reduction of 7-ketocholesterol-induced endothelial glycoprotein (Eng) protein levels. Additionally, Carotuximab inhibited the pSmad1/5 and pSmad2/3 signaling pathways. The blockade of Eng by Carotuximab prevented 7-ketocholesterol-induced monocyte adhesion and migration through endothelial monolayer cells [1]. |
| In vivo | In acute myeloid leukemia (AML) xenografts, the combination of Carotuximab (TRC105) and Decitabine, administered intravenously at a dose of 2 mg/kg once every 3 days for 8 weeks, produces a more durable anti-leukemia effect. Additionally, this combination enhances reactive oxygen species (ROS) activity [2]. |
| Endotoxin | <1.0 EU/mg |
| Synonyms | TRC105, DE-122 |
| Reactivity | Human |
| Verified Activity | Immobilized Human Endoglin/CD105 Protein (His) at 2 μg/mL (30 μL/well) can bind Carotuximab. The EC50 is 43.98 ng/mL. |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Endoglin/CD105 |
| Molecular Weight | 144.8 kDa |
| Cas No. | 1268714-50-6 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Carotuximab chemical structure | Carotuximab in vivo | Carotuximab in vitro | Carotuximab molecular weight
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