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ToP-DNJ
(Synonyms: ToP DNJ) Copy Product Info
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Synonyms: ToP DNJ
Catalog No. T70516 Copy Product Info
Purity: 99.90%
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ToP-DNJ is a selective inhibitor of endoplasmic reticulum α-Glucosidase II and exhibits antiflaviviral activity. ToP-DNJ is relevant for investigations involving viral glycoprotein maturation, endoplasmic reticulum-associated protein processing, and flavivirus-host interaction mechanisms.
Cas No. 1508303-85-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 mg | $1,970 | - | In Stock | |
| 50 mg | $2,580 | - | In Stock | |
| 100 mg | $3,400 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.90%
ee:100%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ToP-DNJ is a selective inhibitor of endoplasmic reticulum α-Glucosidase II and exhibits antiflaviviral activity. ToP-DNJ is relevant for investigations involving viral glycoprotein maturation, endoplasmic reticulum-associated protein processing, and flavivirus-host interaction mechanisms. |
| Targets & IC50 | α-glucosidase II:9μM |
| In vitro | ToP-DNJ is a selective inhibitor of isolated endoplasmic reticulum α-glucosidase II, with IC50 value of 9.0 μM[1]. ToP-DNJ inhibits both catalytic reactions of isolated endoplasmic reticulum α-glucosidase II, showing greater inhibitory potency against the first reaction (IC50 = 14 μM) than the second (IC50 = 56 μM) [1]. ToP-DNJ demonstrates anti-dengue virus activity in primary human monocyte-derived macrophages, with IC50 value of 12.7 μM[1]. |
| In vivo | ToP-DNJ (2–10 mg/kg; i.v., p.o.; single dose) preferentially accumulates in the liver of BALB/c mice following both intravenous and oral single-dose administration, exhibiting an extended plasma terminal half-life of 8.79 h[1]. |
| Synonyms | ToP DNJ |
| Molecular Weight | 662.00 |
| Formula | C40H71NO6 |
| Cas No. | 1508303-85-2 |
| Smiles | CC1=C2C(O[C@@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)CC2)=C(C)C(C)=C1OCCCCCN3[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C3 |
| Storage | Keep away from direct sunlight,Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: ToP-DNJ chemical structure | ToP-DNJ in vivo | ToP-DNJ in vitro | ToP-DNJ formula | ToP-DNJ molecular weight
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