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B2M/beta 2-Microglobulin Protein, Mouse, Recombinant (hFc)
(Synonyms: β-2-microglobulin, Beta-2-microglobulin, B2M/β 2-Microglobulin, B2M) Copy Product InfoSynonyms: β-2-microglobulin, Beta-2-microglobulin, B2M/β 2-Microglobulin, B2M
Catalog No. TMPK-00761 Copy Product Info
The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $42 | 7-10 days | 7-10 days | |
| 10 μg | $64 | 7-10 days | 7-10 days | |
| 20 μg | $98 | 7-10 days | 7-10 days | |
| 50 μg | $195 | 7-10 days | 7-10 days | |
| 100 μg | $323 | 7-10 days | 7-10 days | |
| 200 μg | $587 | 7-10 days | 7-10 days | |
| 500 μg | $1,300 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | P01887 |
| Construction | Ile21-Met119 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | β-2-microglobulin, Beta-2-microglobulin, B2M/β 2-Microglobulin, B2M |
| Research Background |
| Molecular Weight | 38.4 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result. |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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Related Tags: B2M/beta 2-Microglobulin Protein, Mouse, Recombinant (hFc) chemical structure | B2M/beta 2-Microglobulin Protein, Mouse, Recombinant (hFc) molecular weight
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