Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AG 370, an indole tyrphostin, functions as a powerful inhibitor of PDGF-induced mitogenesis, demonstrating an IC50 of 20 μM. Additionally, it exhibits weak inhibition capabilities towards the EGF receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 143.00 | |
5 mg | 35 days | $ 623.00 | |
10 mg | 35 days | $ 1,090.00 | |
25 mg | 35 days | $ 2,390.00 |
Description | AG 370, an indole tyrphostin, functions as a powerful inhibitor of PDGF-induced mitogenesis, demonstrating an IC50 of 20 μM. Additionally, it exhibits weak inhibition capabilities towards the EGF receptor. |
In vitro | AG370 blocks mitogenesis induced by epidermal growth factor (IC50 = 50 microM) and human serum (IC50 = 50 microM). In digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor. [1]. |
Molecular Weight | 259.27 |
Formula | C15H9N5 |
CAS No. | 134036-53-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AG-370 134036-53-6 AG 370 AG370 inhibitor inhibit