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Rosiglitazone hydrochloride

Name: Rosiglitazone hydrochloride
Brand: TargetMol
SKU: T6646
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6646Cas No. 302543-62-0

Alias Rosiglitazone HCl, BRL-49653 HCl

Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Rosiglitazone hydrochloride

🥰Excellent

Purity: 99.79%

Catalog No. T6646Alias Rosiglitazone HCl, BRL-49653 HClCas No. 302543-62-0

Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Pack Size	Price	Availability
25 mg	$33	In Stock
50 mg	$45	In Stock
100 mg	$62	In Stock
200 mg	$88	In Stock
500 mg	$143	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Batch Information

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Purity:99.79%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
Targets&IC50	PPARγ2:100 nM (EC50), PPARγ1:30 nM (EC50), PPARγ:40 nM (Kd)
In vitro	Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. [1] In Bcr-Abl+ leukemia cell lines, Bafetinib induces both caspase-mediated and caspase-independent cell death by blocking the phosphorylation of Bcr-Abl. [2]
Synonyms	Rosiglitazone HCl, BRL-49653 HCl

Chemical Properties

Molecular Weight	393.89
Formula	C₁₈H₁₉N₃O₃S·HCl
Cas No.	302543-62-0
Smiles	Cl.CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 73 mg/mL (185.33 mM), Sonication is recommended.

DMSO: 73 mg/mL (185.33 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (25.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5388 mL	12.6939 mL	25.3878 mL	126.9390 mL
5 mM	0.5078 mL	2.5388 mL	5.0776 mL	25.3878 mL
10 mM	0.2539 mL	1.2694 mL	2.5388 mL	12.6939 mL
20 mM	0.1269 mL	0.6347 mL	1.2694 mL	6.3469 mL
50 mM	0.0508 mL	0.2539 mL	0.5078 mL	2.5388 mL
100 mM	0.0254 mL	0.1269 mL	0.2539 mL	1.2694 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc