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Rosiglitazone hydrochloride

Name: Rosiglitazone hydrochloride
Brand: TargetMol
SKU: T6646
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6646Cas No. 302543-62-0

Alias Rosiglitazone HCl, BRL-49653 HCl

Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Rosiglitazone hydrochloride

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Purity: 99.94%

Catalog No. T6646Alias Rosiglitazone HCl, BRL-49653 HClCas No. 302543-62-0

Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$33	In Stock	In Stock
50 mg	$45	In Stock	In Stock
100 mg	$62	In Stock	In Stock
200 mg	$88	In Stock	In Stock
500 mg	$143	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
Targets&IC50	PPARγ2:100 nM (EC50), PPARγ1:30 nM (EC50), PPARγ:40 nM (Kd)
In vitro	Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. [1] In Bcr-Abl+ leukemia cell lines, Bafetinib induces both caspase-mediated and caspase-independent cell death by blocking the phosphorylation of Bcr-Abl. [2]
Synonyms	Rosiglitazone HCl, BRL-49653 HCl

Chemical Properties

Molecular Weight	393.89
Formula	C₁₈H₁₉N₃O₃S·HCl
Cas No.	302543-62-0
Smiles	Cl.CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 73 mg/mL (185.33 mM), Sonication is recommended.

DMSO: 250 mg/mL (634.69 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (25.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5388 mL	12.6939 mL	25.3878 mL	126.9390 mL
5 mM	0.5078 mL	2.5388 mL	5.0776 mL	25.3878 mL
10 mM	0.2539 mL	1.2694 mL	2.5388 mL	12.6939 mL
20 mM	0.1269 mL	0.6347 mL	1.2694 mL	6.3469 mL
50 mM	0.0508 mL	0.2539 mL	0.5078 mL	2.5388 mL
100 mM	0.0254 mL	0.1269 mL	0.2539 mL	1.2694 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc