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Anti-IGFBP-6 Antibody (1Y17)
🥰Excellent
Catalog No. TMAY-03305
Anti-IGFBP-6 Antibody (1Y17) is a Rabbit antibody targeting IGFBP-6. Anti-IGFBP-6 Antibody (1Y17) can be used in ELISA,IHC-P.
Anti-IGFBP-6 Antibody (1Y17)
Anti-IGFBP-6 Antibody (1Y17)
🥰Excellent
Catalog No. TMAY-03305
Anti-IGFBP-6 Antibody (1Y17) is a Rabbit antibody targeting IGFBP-6. Anti-IGFBP-6 Antibody (1Y17) can be used in ELISA,IHC-P.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IGFBP-6 Antibody (1Y17) is a Rabbit antibody targeting IGFBP-6. Anti-IGFBP-6 Antibody (1Y17) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 1Y17 |
| Reactivity | Mouse |
| Verified Activity | Immunochemical staining of mouse IGFBP6 in mouse skeletal muscle with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IGFBP6 / IBP6 (rM IGFBP6 / IBP6; TMPY-02118; NP_032370.2; Met1-Gly238). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in 20 mM MES, 100 mM NaCl, 10% Trehalose, pH 6.0 |
| Research Background | Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence, and IGF affinity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse IGFBP6 / IBP6 Protein (TMPY-02118) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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