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TargetMol | Tags GPCR/G Protein
TargetMol | Tags Neuroscience

5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.

  • Pimavanserin tartrate
    T6946706782-28-7
    Pimavanserin tartrate (Nuplazid) is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson's disease.
    • $43
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  • Ritanserin
    T1675987051-43-2
    Ritanserin (R 55667) is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM), less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.
    • $34
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  • Capeserod
    T68035769901-96-4
    Capeserod is a potential 5-HT4 receptor (5-hydroxytryptamine receptor 4) agonist for the study of digestive disorders and neurological disorders.
    • $195
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  • AVN-101
    T266901061354-48-0
    AVN-101 is a potent 5-HT7 receptor antagonist.
    • $148
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  • CLOZAPINE N-OXIDE
    T449434233-69-7
    Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.
    • $30
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  • L-(R,S)-Tetrahydropalmatine
    T271410097-84-4
    L-(R,S)-Tetrahydropalmatine (Rotundine) is extracted from Corydalis yanhusuo W. T. Wang.
    • $50
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  • Ziprasidone hydrochloride monohydrate
    T0031138982-67-9
    Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
    • $50
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  • Dopamine hydrochloride
    T164462-31-7
    Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and beta-1- adrenergic receptors.
    • $30
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  • Aripiprazole
    T1566129722-12-9
    Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A.
    • $58
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  • Mianserin hydrochloride
    T078321535-47-7
    Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematological problems.
    • $32
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  • Tianeptine
    T814072797-41-2
    Tianeptine (Tianeptine sodium) is a selective 5-HT uptake facilitator in vitro and in vivo.
    • $81
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  • Fluoxetine hydrochloride
    T0450L56296-78-7
    Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
    • $48
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  • LE 300
    T22921274694-98-3In house
    dopamine D1 receptor antagonist
    • $108
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  • Perphenazine
    T109058-39-9
    Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
    • $29
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  • Trazodone hydrochloride
    T161925332-39-2
    Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety.
    • $39
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  • LY 272015 hydrochloride
    T22948172895-15-7
    LY 272015 hydrochloride is an orally active and selective 5-HT2B receptor antagonist that displays antihypertensive effects in DOCA-salt hypertensive rats.LY 272015 hydrochloride inhibits 5-HT- or BW723C86-induced ERK2 phosphorylation and attenuates MVIC and Tissue downstream cellular effects of 5HT signaling and can be used to study hepatocellular carcinoma.
    • $55
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  • Dapoxetine hydrochloride
    T6461129938-20-1
    Dapoxetine hydrochloride (LY-210448 hydrochloride) is a selectivity short-acting serotonin reuptake inhibitor, used for the therapy of premature ejaculation.
    • $30
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  • Lesopitron HCl
    T11839L132449-88-8In house
    Lesopitron HCl is a 5-HT1A receptor agonist with anxiolytic effects that reverses dark avoidance behavior associated with cocaine withdrawal in mice.
    • $700
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  • Vilazodone
    T1279163521-12-8
    Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from the synaptic cleft while stimulating the release of 5-HT into the synaptic cleft. This increases the concentration of 5-HT in the synaptic cleft and potentiates serotonergic neurotransmission in the central nervous system.
    • $54
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  • Cannabigerol
    TN146525654-31-3
    Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressure, which may be of benefit in the treatment of glaucoma.
    • $148
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  • (+)-OSU 6162
    T60027160777-43-5In house
    (+)-OSU 6162 (Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, (3R)-) is an agonist of 5-HT Receptor with anti-Alzheimer and antidepressant activities.
    • $117
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  • Faxeladol
    T31750433265-65-7In house
    Faxeladol, a potent adrenergic absorption inhibitor and serotonin reuptake inhibitor, is a small-molecule Opioid receptor agonist that can be used to study neurological disorders.
    • $628
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  • Tabernanthalog
    T602212483829-58-7
    Tabernanthalog (TBG) is a 5-HT2A agonist. In rodents,Tabernanthalog has been found to promote structural neuroplasticity, reduce alcohol-seeking and heroin-seeking behavior, and produce antidepressant effects.
    • $195
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  • DA-6886
    T271171645260-76-9In house
    DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels.
    • $140
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  • SB 699551 dihydrochloride
    T23325864741-95-7
    SB 699551 dihydrochloride is a 5-ht5a receptor antagonist.
    • $73
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  • Landipirdine
    T277951000308-25-7In house
    Landipirdine (RO-5025181) is a selective 5-HT6R antagonist for the study of central nervous system disorders such as dementia.
    • $293
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  • L-745870 trihydrochloride
    T22904866021-03-6
    L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
    • $68
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  • LY-2624803
    T24421879409-35-5In house
    LY-2624803 is a 5-HT2A receptor antagonist and histamine receptor inverse agonist that can be used to improve slow wave sleep.
    • $143
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  • 5-HT7 agonist 1
    T10170334974-31-1In house
    5-HT7 agonist 1 (4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole) is a selective agonist of 5-HT7 (IC50 = 222.93 nM). 5-HT7 agonist 1 can be used in studies about CNS disorders.
    • $117
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  • RS 42358-197
    T20739135729-55-4
    RS 42358-197 (RS 25259-007) is a competitive 5-HT3 receptor antagonist.
    • $282
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  • Enciprazine
    T2726268576-86-3In house
    Enciprazine (D-3112) has anxiolytic activity with high affinity for 5-HT1A receptor and ADRA1, which can be used for the treatment of anxiety disorders and can be used to study depression.
    • $293 TargetMol
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  • (4E)-SUN9221
    T12596222318-55-0
    (4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist that shows antihypertensive and antiplatelet aggregation activity in hypertensive rats.
    • $700
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  • Org-13011 fumarate
    T28258142494-13-1In house
    Org-13011 fumarate1 is an agonist of the 5-HT1A receptor and can be used to study neurological disorders.
    • $293
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  • Pimethixene
    T12489314-03-4
    Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively).
    • $35
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  • SLV-310
    T28809264869-71-8In house
    SLV-310 is a potent dopamine D2 receptor antagonist and 5-HT reuptake receptor inhibitor used in the study of neurological disorders such as bipolar disorder and schizophrenia.
    • $293 TargetMol
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  • Pancopride
    T16433121650-80-4
    Pancopride(LAS 30451) is a novel, orally available, long-acting, selective 5-HT3 receptor antagonist that blocks nitrogen mustard and dacarbazine-induced vomiting.
    • $700
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  • PRX933 hydrochloride
    T12565639029-42-8In house
    PRX933 hydrochloride (GW876167 hydrochloride) is an agonist of 5-HT2C receptor and can be used in studies about hypertension acute treatment.
    • $375
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  • MM 77 dihydrochloride
    T23007159187-70-9
    MM 77 dihydrochloride is an effecitve 5-HT1A receptor postsynaptic antagonist with anxiolytic-like activity.
    • $78
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  • Lintopride HCl
    T15760L268548-31-8In house
    Lintopride HCl is a 5HT-4 antagonist.
    • $89 TargetMol
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  • SB 258585
    T23318L209480-63-7
    SB 258585 is a selective 5-HT6 receptor antagonist.SB 258585 has a high affinity for individual receptor populations in cell lines with human recombinant 5-HT6 receptors.SB 258585 can be used to label both recombinant and natural 5-HT6 receptors, and can be used to assay cognitive enhancement and antipsychotic activity.
    • $41
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  • Viloxazine
    T6032546817-91-8In house
    Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2B receptors, with respective potency values of EC 50 = 32 μM and IC 50 = 27 μM. Its primary mechanism of action involves the modulation of serotonergic and noradrenergic pathways. Viloxazine is commonly employed in depression research [1] [2].
    • $195
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  • Lensiprazine
    T32633327026-93-7In house
    Lensiprazine (SLV314) is a potent dopamine D(2) receptor antagonist that acts as a serotonin reuptake inhibitor , and can be used to study bipolar disorder and schizophrenia.
    • $191
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  • Rilapine
    T2608579781-95-6In house
    Rilapine (Rilapinum) is an antipsychotic compound that shows high affinity for 5-HT6 receptors and can be used to study neurological disorders.
    • $293
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  • CP 96021
    T10872L139401-43-7In house
    CP 96021 is a group of 5-HT1 receptors and 5-HT2 receptors antagonists that have anti-inflammatory properties and are non-non-self anti-ulcer compounds for the treatment of gastrointestinal tract and respiratory asthma.
    • $195
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  • 5HT6-ligand-1
    T100531038988-11-2In house
    5HT6-ligand-1 is an orally active ligand of 5-HT6 receptor (Ki = 1.43 nM).
    • $197
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  • Aplindore Fumarate
    T30098189681-71-8In house
    Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-HT2), and α1-adrenergic receptors.Aplindore Fumarate is used in the study of Parkinson's disease and schizophrenia. Fumarate can be used to study Parkinson's and schizophrenia.
    • $293
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  • Abaperidone
    T14083183849-43-6In house
    Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound that reduces basal hsp70 mRNA expression in rat striatum and prefrontal cortex. expression in the striatum and prefrontal cortex of rats.
    • $350
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  • NLX-204 hydrochloride(2170405-10-2 free base)
    T22379L
    NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
    • $54
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  • Binospirone
    T71138L102908-59-8In house
    Binospirone (MDL 73005EF) is a 5-HT1A receptor agonist with anxiolytic activity used in the study of glaucoma and movement disorders associated with neurologic dysfunction.
    • $195 TargetMol
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  • S 16924
    T28638734513-52-1In house
    S 16924 is a 5-HT 1A agonist with potential anxiolytic effects and may be useful in the study of neurologic disorders.
    • $293 TargetMol
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