RIPK3-IN-1

Name: RIPK3-IN-1
Brand: TargetMol
SKU: T63544
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63544Cas No. 2361139-70-8

RIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities of c-Met kinase, RIPK1 and RIPK2.RIPK3-IN-1 has potential tumorigenic activity and can be used to study apoptosis.

RIPK3-IN-1

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Purity: 98.27%

Catalog No. T63544Cas No. 2361139-70-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	-	In Stock
5 mg	$172	-	In Stock
10 mg	$289	-	In Stock
25 mg	$587	In Stock	In Stock
50 mg	$953	-	In Stock
100 mg	$1,520	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.27%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	RIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities of c-Met kinase, RIPK1 and RIPK2.RIPK3-IN-1 has potential tumorigenic activity and can be used to study apoptosis.
Targets&IC50	SRC:0.075 μM, ABL:0.37 μM, RIPK3:9.1 nM, MAP4K3:0.012 μM, B-Raf:0.15 μM
In vitro	RIPK3-IN-1 inhibits ABL, BRAF/V599E, MAP4K3, and SRC with IC50 values of 0.37, 0.15, 0.012, and 0.075 μM, respectively[1].

Chemical Properties

Molecular Weight	512.53
Formula	C₂₉H₂₅FN₄O₄
Cas No.	2361139-70-8
Smiles	Cc1c(C)c(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)c1cccn(-c2ccc(F)cc2)c1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc