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Telenzepine dihydrochloride

Name: Telenzepine dihydrochloride
Brand: TargetMol
SKU: T23452
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T23452 Copy Product Info

Purity: 99.49%

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Telenzepine dihydrochloride is a highly selective M1 muscarinic receptor antagonist. It inhibits gastric acid secretion and is used for ulcer and cholinergic neuropharmacology research.

Telenzepine dihydrochloride

Copy Product Info

🥰Excellent

Catalog No. T23452

Telenzepine dihydrochloride is a highly selective M1 muscarinic receptor antagonist. It inhibits gastric acid secretion and is used for ulcer and cholinergic neuropharmacology research.

Cas No. 147416-96-4

Pack Size	Price	USA Stock	Global Stock
2 mg	$30	-	In Stock
5 mg	$48	-	In Stock
10 mg	$79	-	In Stock
25 mg	$158	-	In Stock
50 mg	$256	-	In Stock
100 mg	$412	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.49%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Telenzepine dihydrochloride is a highly selective M1 muscarinic receptor antagonist. It inhibits gastric acid secretion and is used for ulcer and cholinergic neuropharmacology research.
Targets&IC50	M1 mAChR:0.94 nM (Ki), M2 mAChR:17.8 nM (Ki)
In vitro	Telenzepine dihydrochloride (100 nM) blocks muscarine-induced responses and inhibits M1 receptor-mediated depolarization (IC50 = 8.5 nM) [2][3].
In vivo	Telenzepine dihydrochloride potently inhibits gastric acid secretion in rats; oral 2.7 umol/kg shows long-lasting anti-ulcer effects [1].

Chemical Properties

Molecular Weight	406.93
Formula	C₁₉H₂₄Cl₂N₄O₂S
Cas No.	147416-96-4
Smiles	O=C1NC2=C(N(C3=C(C)SC=C31)C(CN4CCN(CC4)C)=O)C=CC=C2.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (122.87 mM), Sonication is recommmended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.4574 mL	12.2871 mL	24.5743 mL	122.8713 mL
5 mM	0.4915 mL	2.4574 mL	4.9149 mL	24.5743 mL
10 mM	0.2457 mL	1.2287 mL	2.4574 mL	12.2871 mL
20 mM	0.1229 mL	0.6144 mL	1.2287 mL	6.1436 mL
50 mM	0.0491 mL	0.2457 mL	0.4915 mL	2.4574 mL
100 mM	0.0246 mL	0.1229 mL	0.2457 mL	1.2287 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc