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PD153035

Name: PD153035
Brand: TargetMol
SKU: T2041
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2041Cas No. 153436-54-5

Alias ZM 252868, SU-5271, NSC 669364, AG1517

PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR, PGDFR, InsR, CSF-1 and Src.

PD153035

🥰Excellent

Purity: 99.29%

Catalog No. T2041Alias ZM 252868, SU-5271, NSC 669364, AG1517Cas No. 153436-54-5

PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR, PGDFR, InsR, CSF-1 and Src.

Pack Size	Price	Availability
10 mg	$35	In Stock
25 mg	$73	In Stock
50 mg	$135	In Stock
100 mg	$236	In Stock
200 mg	$353	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock

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Batch Information

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Purity:99.29%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR, PGDFR, InsR, CSF-1 and Src.
Targets&IC50	EGFR:29 pM
Synonyms	ZM 252868, SU-5271, NSC 669364, AG1517

Chemical Properties

Molecular Weight	360.21
Formula	C₁₆H₁₄BrN₃O₂
Cas No.	153436-54-5
Smiles	COC1=CC2=NC=NC(NC3=CC(Br)=CC=C3)=C2C=C1OC
Relative Density.	1.499 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (13.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7762 mL	13.8808 mL	27.7616 mL	138.8079 mL
5 mM	0.5552 mL	2.7762 mL	5.5523 mL	27.7616 mL
10 mM	0.2776 mL	1.3881 mL	2.7762 mL	13.8808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc