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PD153035
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Catalog No. T2041Cas No. 153436-54-5
Alias ZM 252868, SU-5271, NSC 669364, AG1517
PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR, PGDFR, InsR, CSF-1 and Src.
PD153035
Copy Product Info🥰Excellent
Purity: 99.29%
Catalog No. T2041Alias ZM 252868, SU-5271, NSC 669364, AG1517Cas No. 153436-54-5
PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR, PGDFR, InsR, CSF-1 and Src.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $35 | In Stock | In Stock | |
| 25 mg | $73 | In Stock | In Stock | |
| 50 mg | $135 | In Stock | In Stock | |
| 100 mg | $236 | In Stock | In Stock | |
| 200 mg | $353 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $34 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.29%
Appearance:Solid
Color:White
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Product Introduction
PD153035 AI Summary
PD153035 demonstrates significant bioactivity as a potent inhibitor of the Epidermal Growth Factor Receptor (EGFR) tyrosine kinase activity with an exceptionally low IC50 value of 0.025 nM. This compound also inhibits the phosphorylation of phospholipase C-gamma1 by EGFR at the same IC50 value, highlighting its strong affinity for EGFR. Additionally, PD153035 shows inhibitory activity against other kinases such as v-Abl tyrosine kinase and c-Src tyrosine kinase, with varying efficacy. It also exhibits antiproliferative effects on various cancer cell lines, including human A431 cells, with IC50 values ranging from nanomolar to micromolar concentrations. Furthermore, it demonstrates a broad spectrum of activity against other targets, such as fructose-1,6-bisphosphatase and MNK1 kinase, and it possesses cytotoxic properties in specific cancer cell lines. These findings highlight PD153035's potential as a therapeutic candidate for EGFR-related diseases and cancer treatment..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR, PGDFR, InsR, CSF-1 and Src. |
| Targets&IC50 | EGFR:29 pM |
| Synonyms | ZM 252868, SU-5271, NSC 669364, AG1517 |
| Molecular Weight | 360.21 |
| Formula | C16H14BrN3O2 |
| Cas No. | 153436-54-5 |
| Smiles | COC1=CC2=NC=NC(NC3=CC(Br)=CC=C3)=C2C=C1OC |
| Relative Density. | 1.499 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (13.88 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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