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Isoformononetin

Name: Isoformononetin
Brand: TargetMol
SKU: TN1778
Rating: 4.5 (1 reviews)

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Catalog No. TN1778Cas No. 486-63-5

Alias Dehydroevodiamine, 4''-Hydroxy-7-Methoxyisoflavone

Isoformononetin (IFN) is a methoxy isoflavone present in human dietary supplements that exhibits immune-protective effects by preventing neuroinflammation in a streptozotocin-induced rat model through inhibition of the NLRP3/ASC/IL-1 axis activation.

Isoformononetin

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Catalog No. TN1778Alias Dehydroevodiamine, 4''-Hydroxy-7-MethoxyisoflavoneCas No. 486-63-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$206	7-10 days	7-10 days
5 mg	$515	7-10 days	7-10 days
10 mg	$820	7-10 days	7-10 days
25 mg	$1,476	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Isoformononetin (IFN) is a methoxy isoflavone present in human dietary supplements that exhibits immune-protective effects by preventing neuroinflammation in a streptozotocin-induced rat model through inhibition of the NLRP3/ASC/IL-1 axis activation.
In vitro	Isoformononetinn (10-8 M) promotes differentiation of osteoblasts involved in activation of the MEK-Erk and Akt pathways and exhibits potent anti-apoptotic effects. [2]
In vivo	Isoformononetin was administered orally at a dose of 10mg/kg once a day for 21 days, and the results showed that Isoformononetin was neuroprotective against STZ-induced inflammation. [1] Isoformononetin (10.0 mg/kg/ day) tube feeding can increase the bone mineral density (BMD) of bone site and promote the growth and development of uterus in SD rats. [2]
Synonyms	Dehydroevodiamine, 4''-Hydroxy-7-Methoxyisoflavone

Chemical Properties

Molecular Weight	268.26
Formula	C₁₆H₁₂O₄
Cas No.	486-63-5
Smiles	O=C1C(=COC2=CC(OC)=CC=C21)C=3C=CC(O)=CC3
Relative Density.	1.329 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (745.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7277 mL	18.6386 mL	37.2773 mL	186.3863 mL
5 mM	0.7455 mL	3.7277 mL	7.4555 mL	37.2773 mL
10 mM	0.3728 mL	1.8639 mL	3.7277 mL	18.6386 mL
20 mM	0.1864 mL	0.9319 mL	1.8639 mL	9.3193 mL
50 mM	0.0746 mL	0.3728 mL	0.7455 mL	3.7277 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8639 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Isoformononetin