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PA3552-IN-1

Name: PA3552-IN-1
Brand: TargetMol
SKU: T67912
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67912Cas No. 1008121-12-7

PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B.

PA3552-IN-1

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Purity: 99.82%

Catalog No. T67912Cas No. 1008121-12-7

PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	-	In Stock
25 mg	$83	-	In Stock
50 mg	$138	-	In Stock
100 mg	$209	-	In Stock
200 mg	$295	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

PA3552-IN-1 AI Summary

PA3552-IN-1 exhibits notable cytotoxic effects against human cancer cell lines HL60, KG1, Jurkat, and NALM6, with IC50 values of 280.0 nM, 490.0 nM, 530.0 nM, and 910.0 nM respectively. It also inhibits the binding between KIX-RLucN fused CBP and KID-RLucC fused CREB in human HEK293 cells with an IC50 of 1520.0 nM. Additionally, PA3552-IN-1 shows bioactivity against the Zika virus by inhibiting NS-1 and envelope protein with IC50 values of 1720.0 nM and 1340.0 nM, respectively. With a solubility of 3.3 µg/mL, the compound also demonstrates cytotoxicity against African Green monkey Vero E6 cells with a CC50 of 8150.0 nM and exhibits good permeability in a PAMPA assay with a permeability value of 30.7 x 10^-6 cm/s. Moreover, PA3552-IN-1 shows antimicrobial activity against strains such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. It presents synergistic antibacterial effects when combined with polymyxin B and significantly reduces bacterial growth, enhancing survival rates in Caenorhabditis elegans infected with Pseudomonas aeruginosa. The compound also suppresses drug resistance development in Pseudomonas aeruginosa but exhibits acute toxicity in ICR mice at high doses..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B.

Chemical Properties

Molecular Weight	310.67
Formula	C₁₃H₈ClFN₂O₄
Cas No.	1008121-12-7
Smiles	Oc1ccc(F)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
Relative Density.	1.595 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12.5 mg/mL (40.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2188 mL	16.0942 mL	32.1885 mL	160.9425 mL
5 mM	0.6438 mL	3.2188 mL	6.4377 mL	32.1885 mL
10 mM	0.3219 mL	1.6094 mL	3.2188 mL	16.0942 mL
20 mM	0.1609 mL	0.8047 mL	1.6094 mL	8.0471 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc